| Can a single vasodilator be responsible for both coronary autoregulation and metabolic vasodilation? | |
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MedLine Citation:
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PMID: 7283936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To test the hypothesis that both coronary autoregulation and metabolic vasodilation can be mediated by the same substance, we have analysed measured autoregulation curves with the aid of a simple mass balance model. In an open-chest dog preparation, increasing the heart rate by pacing results in a nearly parallel shift of the autoregulation curve to a higher flow (Q) level. We assume a unique relationship between vascular conductance and interstitial concentration of a vasodilating substance [A]. Applying a compartmental mass balance, it is possible to predict with a minimum of assumptions the increase of flow between two points with increased production but having the same vasodilator concentration. The simple result of this analysis is: delta Q = delta production/[A]. If the vasodilator concentration varies by more than a factor 2 between low and high conductance points, the autoregulation curve cannot shift in a parallel fashion as a result of an increased production rate, but rather will become less and less steep. We conclude that a single vasodilator cannot be responsible for both autoregulation and metabolic vasodilation unless complex assumptions are made, for which there is as yet no experimental support. |
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Authors:
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J D Laird; P N Breuls; P van der Meer; J A Spaan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Basic research in cardiology Volume: 76 ISSN: 0300-8428 ISO Abbreviation: Basic Res. Cardiol. Publication Date: 1981 Jul-Aug |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0360342 Medline TA: Basic Res Cardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 354-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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metabolism,
pharmacology* Animals Coronary Circulation / drug effects* Dogs Homeostasis / drug effects* Models, Cardiovascular* Myocardium / metabolism Oxygen Consumption / drug effects Vasodilation / drug effects* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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