| Can simultaneous contact allergies to phenyl glycidyl ether and epoxy resins of the bisphenol A/F-types be explained by contamination of the epoxy resins? | |
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MedLine Citation:
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PMID: 18976377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Simultaneous contact allergies to epoxy resins based on diglycidyl ether of bisphenol A (DGEBA-R) or epoxy resins of the bisphenol F-type and the reactive diluent phenyl glycidyl ether (PGE) have been reported. The reason might be cross-reactivity, exposure to an epoxy resin system with PGE as a component, or contamination by PGE in the epoxy resin. AIMS: To study contamination by PGE, 20 commercial epoxy resins were analysed for the presence of PGE. To study contact allergy to PGE and its relation to epoxy resins by inserting PGE in the standard series. RESULTS: Among 2227 patients, 7 reacted to PGE. Of 23 (30%) patients, 7 with contact allergy to DGEBA-R and 7/19 (37%) with contact allergy to an epoxy resin of the bisphenol F-type reacted to PGE. All 7 patients with contact allergy to PGE reacted both to the DGEBA-R and to the epoxy resin of the bisphenol F-type. PGE was found in 90% of the investigated resins. The amounts of PGE ranged between 0.004% w/w and 0.18% w/w. CONCLUSION: Most probably, the presence of PGE as a contaminant in epoxy resins is of minor importance for the sensitization, but possibly the contamination of PGE might elicit contact dermatitis in individuals with a high reactivity to PGE. |
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Authors:
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Ann Pontén; Erik Zimerson; Magnus Bruze |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Contact dermatitis Volume: 59 ISSN: 1600-0536 ISO Abbreviation: Contact Derm. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-11-03 Completed Date: 2009-02-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7604950 Medline TA: Contact Dermatitis Country: Denmark |
Other Details:
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Languages: eng Pagination: 273-9 Citation Subset: IM |
Affiliation:
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Department of Occupational and Environmental Dermatology, Lund University, Malmö University Hospital, SE-20502 Malmö, Sweden. ann.ponten@skane.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Allergens / chemistry, diagnostic use* Cohort Studies Dermatitis, Allergic Contact / diagnosis*, epidemiology, etiology Dermatitis, Occupational / diagnosis*, epidemiology, etiology Epoxy Compounds / chemistry, diagnostic use Epoxy Resins / chemistry, diagnostic use* Female Humans Incidence Male Mass Spectrometry Middle Aged Occupational Exposure / adverse effects Patch Tests Phenols / chemistry, diagnostic use Retrospective Studies Risk Factors Severity of Illness Index Sweden / epidemiology Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Allergens; 0/Epoxy Compounds; 0/Epoxy Resins; 0/Phenols; 0/bisphenol F diglycidyl ether; 80-05-7/bisphenol A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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