Document Detail

Can sequencing shed light on cell cycling?
MedLine Citation:
PMID:  11237006     Owner:  NLM     Status:  MEDLINE    
Every organism must have cells that can replicate indefinitely. Can the draft human genome sequence tell us how the cell cycle works and how it evolved? We studied two protein families--the cyclins and their partners the cyclin-dependent kinases (Cdks)--and a conserved regulatory circuit, the spindle checkpoint. Disappointingly, we discovered a few novel cyclins and no new Cdks or components of the spindle checkpoint, and could shed little light on the organization of the cell cycle.
A W Murray; D Marks
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  409     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  2001 Feb 
Date Detail:
Created Date:  2001-03-09     Completed Date:  2001-03-22     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  844-6     Citation Subset:  IM    
Center for Genomics Research, Harvard University, Cambridge, Massachusetts 02138, USA.
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MeSH Terms
Amino Acid Sequence
Cell Cycle / genetics*
Cyclin-Dependent Kinases / genetics*
Cyclins / genetics*
Genes, cdc*
Genome, Human*
Human Genome Project
Mitotic Spindle Apparatus / genetics
Molecular Sequence Data
Sequence Alignment
Reg. No./Substance:
0/Cyclins; EC Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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