Document Detail

Can screening for retinopathy of prematurity be reduced?
MedLine Citation:
PMID:  15855744     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: As screening for retinopathy of prematurity (ROP) is costly, time-consuming for the ophthalmologist and discomforting for the neonate, the minimum number of infants should be screened for ROP, without missing infants with severe ROP, at risk for threshold ROP. OBJECTIVES: To develop a diagnostic screening guideline for ROP that would safely reduce the number of ROP screening funduscopies in our department. METHODS: Data of 275 infants admitted between 1996 and 2000 and screened for ROP according to our Dutch National guideline were studied. Significant risk factors for ROP were calculated, using logistic regression analysis and used to develop a guideline. The discriminative power of the guideline was evaluated using the area under the curve for the receiver operating characteristic curve. RESULTS: Significant risk factors for ROP were: gestational age, birth weight and number of erythrocyte transfusions within the first 4 weeks of life. The combination of these 3 factors resulted in the highest area under the curve: 0.793. Using these 3 factors, a diagnostic screening guideline for ROP was developed: if birth weight + 2 x (gestational age - 20) - 6 x erythrocyte transfusion value within the first 4 weeks of life >or=34, no screening for ROP is necessary. Using this guideline, 22.2% of the infants of the study group could have been excluded from screening; 3.8% of the infants with ROP stages 1-2 would have been missed. CONCLUSION: In our department, ROP screening can be safely reduced using our diagnostic screening guideline.
J U M Termote; A R T Donders; N E Schalij-Delfos; C H Lenselink; C S Derkzen van Angeren; S C J L Lissone; B P Cats
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Publication Detail:
Type:  Journal Article     Date:  2005-04-22
Journal Detail:
Title:  Biology of the neonate     Volume:  88     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2005  
Date Detail:
Created Date:  2005-08-11     Completed Date:  2005-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  92-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Department of Neonatology, Wilhelmina Children's Hospital/University Medical Center, Utrecht, The Netherlands.
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MeSH Terms
Birth Weight
Erythrocyte Transfusion
Gestational Age
Infant, Newborn
Infant, Premature
Neonatal Screening*
Retinopathy of Prematurity / diagnosis*,  therapy
Risk Factors
Comment In:
Biol Neonate. 2005;88(2):98-100   [PMID:  15855745 ]

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