Document Detail


Can recent insights into cardiac development improve our understanding of congenitally malformed hearts?
MedLine Citation:
PMID:  19031393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congenital cardiac malformations account for one-quarter of all human congenital abnormalities. They are caused by environmental and genetic factors. Despite increasing efforts in fundamental research, as yet, the morphogenesis of only a limited number of malformations has been elucidated. Over the last decades, new genetic modifications have made it possible to manipulate the mammalian embryo. Evidence provided using these transgenic techniques has, over the past decade, necessitated re-evaluation of several developmental processes, important in the understanding of normal as opposed to abnormal cardiac development. In this review, we discuss current understanding of the patterning of the initial heart tube, new insights into formation of the atrial and ventricular chambers, and novel information on the origin of the cells that are added to the heart after formation of the initial tube. All of these advances modify our appreciation of malformations involving the venous and arterial poles. As we demonstrate, this new information sheds light not only on normal cardiac development, but also explains the structure of several previously controversial lesions seen in malformed human hearts.
Authors:
Thomas Horsthuis; Vincent M Christoffels; Robert H Anderson; Antoon F M Moorman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical anatomy (New York, N.Y.)     Volume:  22     ISSN:  1098-2353     ISO Abbreviation:  Clin Anat     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-05     Completed Date:  2009-03-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809128     Medline TA:  Clin Anat     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-20     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Affiliation:
Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15, Amsterdam, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Patterning / genetics*
Cells, Cultured
Disease Models, Animal
Embryonic Development / genetics*
Heart / embryology*
Heart Defects, Congenital / pathology*
Humans
Mice
Mice, Transgenic
Organogenesis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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