Document Detail

Can primary dysmenorrhea be alleviated by a vasopressin antagonist? Results of a pilot study.
MedLine Citation:
PMID:  3321865     Owner:  NLM     Status:  MEDLINE    
In order to study the etiological role of vasopressin in primary dysmenorrhea the therapeutic effect of an antagonist of vasopressin action on the uterus (1-deamino-2-D-Tyr(OEt)-4-Thr-8-Orn-oxytocin) was investigated in 14 patients with moderate to severe symptoms. The women participated in the study at two menstruations and each time one intravenous bolus injection of the analogue (10 micrograms/kg body weight) and one of the placebo (saline) were given, randomized and double-blind with at least a 2 hour interval. The effect was monitored by overall ratings and by pain diagrams described by the patients. In the former parameter the vasopressin antagonist was significantly more effective (p less than 0.01). In the pain diagrams, however, a significant reduction of symptoms occurred both after the analogue administrations and after placebo given as second injection. The results support a causative role of vasopressin in primary dysmenorrhea, but further studies with higher doses and/or other routes of administration or delivery systems are required in order to delineate the therapeutic value of vasopressin antagonists in the condition.
M Akerlund
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  66     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1987  
Date Detail:
Created Date:  1988-02-20     Completed Date:  1988-02-20     Revised Date:  2008-09-03    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  459-61     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University Hospital of Lund, Sweden.
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MeSH Terms
Clinical Trials as Topic
Double-Blind Method
Dysmenorrhea / drug therapy*
Injections, Intravenous
Pilot Projects
Vasotocin / administration & dosage,  analogs & derivatives*,  therapeutic use
Reg. No./Substance:
9034-50-8/Vasotocin; 90779-69-4/atosiban

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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