| Can preoperative myocardial perfusion scintigraphy predict changes in left ventricular perfusion and function after coronary artery bypass graft surgery? | |
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MedLine Citation:
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PMID: 22473665 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES We wanted to evaluate whether preoperative myocardial perfusion scintigraphy (MPS) could predict changes in cardiac symptoms and postoperative myocardial perfusion and left ventricular function after coronary artery bypass grafting (CABG). METHODS Ninety-two patients with stable angina pectoris (and at least one occluded coronary artery) underwent MPS before, and 6 months after, undergoing CABG. The result of the MPS was kept secret from the surgeons. RESULTS Before CABG, 90% of the patients had angina. After CABG, 97% of the patients were without symptoms. Overall graft patency was 84%. Before CABG, one patient had normal perfusion; in the rest of them the defects were classified as follows: reversible (60%), partly reversible (27%) and irreversible (12%). Following CABG, 33% had normal perfusion; in the rest the defects were reversible in 29%, partly reversible in 12% and irreversible in 26%. Left ventricular ejection fraction (LVEF), which was normal before operation in 45%, improved in 40% of all patients. The increase in LVEF was not related to the preoperative pattern of perfusion defects. Of 30 patients with normalized perfusion after CABG, 29 (97%) had reversible defects and one patient had partly reversible defects. Of 83 perfusion defects, which were normalized after CABG, 67 were reversible (81%) or partly reversible (12%). Seventy-five percent of all reversible coronary artery territories before CABG were normalized after operation. CONCLUSIONS Our results indicate that reversible or partly reversible perfusion defects at a preoperative MPS have a high chance of normalized myocardial perfusion assessed by MPS 6 months after operation. Normal perfusion is obtained almost exclusively in territories with reversible ischaemia. Symptoms improved in nearly all patients and LVEF in a significant fraction of the patients, not related to preoperative MPS. |
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Authors:
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Rozy Eckardt; Bo Juel Kjeldsen; Allan Johansen; Peter Grupe; Torben Haghfelt; Per Thayssen; Lars Ib Andersen; Birger Hesse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-02 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 14 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-16 Completed Date: 2012-09-07 Revised Date: 2013-06-05 |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 779-84 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Institute of Clinical Research, Odense University Hospital, Odense, Denmark. rozy@eckardtmail.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angina Pectoris / physiopathology, radionuclide imaging, surgery Coronary Angiography Coronary Artery Bypass* / adverse effects Coronary Artery Disease / physiopathology, radionuclide imaging*, surgery* Coronary Circulation* Denmark Female Humans Male Middle Aged Myocardial Perfusion Imaging / methods* Predictive Value of Tests Preoperative Care Prospective Studies Radiopharmaceuticals / diagnostic use Recovery of Function Stroke Volume* Technetium Tc 99m Sestamibi / diagnostic use Time Factors Treatment Outcome Vascular Patency* Ventricular Function, Left* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 109581-73-9/Technetium Tc 99m Sestamibi |
| Comments/Corrections | |
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