Document Detail

Can prenatal ultrasound detect the effects of in-utero alcohol exposure? A pilot study.
MedLine Citation:
PMID:  19444822     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this pilot study was to explore possible ultrasound parameters for the early detection of alcohol-mediated fetal somatic and central nervous system (CNS) maldevelopment. Maternal alcohol ingestion during pregnancy may lead to fetal alcohol spectrum disorders (FASD), which encompass a broad range of structural abnormalities including growth impairment, specific craniofacial features and CNS abnormalities. Early detection of fetuses at risk of FASD would support earlier interventions.
METHODS: We performed a longitudinal prospective pilot study from 2004 to 2006 at two sites in Ukraine. A sample of pregnant women who reported consuming moderate-to-heavy amounts of alcohol participated in a comprehensive maternal interview, and received ultrasound evaluation of fetal growth and specific fetal brain measurements during the second and third trimesters. These measurements were compared with those collected from a group of pregnant women who consumed little-to-no alcohol during pregnancy, and who were recruited and followed in the same manner.
RESULTS: From 6745 screened women, 84 moderate-to-heavy alcohol users and 82 comparison women were identified and ultrasound examinations performed. After controlling for maternal smoking, alcohol-exposed fetuses had shorter mean femur length, caval-calvarial distance and frontothalamic measurements in the second trimester (P < 0.05), and alcohol-exposed fetuses also had shorter frontothalamic distance measurements in the third trimester relative to comparison fetuses (P < 0.05). In addition, after controlling for maternal smoking, both mean orbital diameter and biparietal diameter measurements were significantly smaller on average in the alcohol-exposed group in the third trimester relative to comparison fetuses (P < 0.05).
CONCLUSIONS: Significant differences in selected somatic and brain measurements were noted between alcohol-exposed and comparison fetuses, suggesting these markers may be further explored for clinical utility in prenatal identification of affected children. Further study correlating these findings with alcohol-related physical features of the newborn and subsequent comparisons of neuro-developmental outcomes will help define potential uses of prenatal ultrasound for intervention and prevention of FASD.
M Kfir; L Yevtushok; S Onishchenko; W Wertelecki; L Bakhireva; C D Chambers; K L Jones; A D Hull
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  33     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2010-07-13     Revised Date:  2014-03-27    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  683-9     Citation Subset:  IM    
Copyright Information:
(c) 2009 ISUOG.
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MeSH Terms
Abnormalities, Drug-Induced / epidemiology,  ultrasonography*
Epidemiologic Methods
Fetal Alcohol Spectrum Disorders / epidemiology,  ultrasonography*
Fetal Development / drug effects
Maternal-Fetal Exchange
Pilot Projects
Pregnancy Trimester, Second
Prenatal Care
Prenatal Exposure Delayed Effects / epidemiology,  ultrasonography*
Ultrasonography, Prenatal / methods*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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