| Can prenatal N-3 fatty acid deficiency be completely reversed after birth? Effects on retinal and brain biochemistry and visual function in rhesus monkeys. | |
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MedLine Citation:
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PMID: 16257925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our previous studies of rhesus monkeys showed that combined prenatal and postnatal n-3 fatty acid deficiency resulted in reduced visual acuity, abnormal retinal function, and low retina and brain docosahexaenoic acid content. We now report effects of n-3 fatty acid deficiency during intrauterine development only. Rhesus infants, born to mothers fed an n-3 fatty acid deficient diet throughout pregnancy, were repleted with a diet high in alpha-linolenic acid from birth to 3 y. Fatty acid composition was determined for plasma and erythrocytes at several time points, for prefrontal cerebral cortex biopsies at 15, 30, 45, and 60 wk, and for cerebral cortex and retina at 3 y. Visual acuity was determined behaviorally at 4, 8, and 12 postnatal weeks, and the electroretinogram was recorded at 3-4 mo. Total n-3 fatty acids were reduced by 70-90% in plasma, erythrocytes, and tissues at birth but recovered to control values within 4 wk in plasma, 8 wk in erythrocytes, and 15 wk in cerebral cortex. At 3 y, fatty acid composition was normal in brain phospholipids, but in the retina DHA recovery was incomplete (84% of controls). Visual acuity thresholds did not differ from those of control infants from mothers fed a high linolenic acid diet. However, the repleted group had lower amplitudes of cone and rod ERG a-waves. These data suggest that restriction of n-3 fatty acid intake during the prenatal period may have long-term effects on retinal fatty acid composition and function. |
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Authors:
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Gregory J Anderson; Martha Neuringer; Don S Lin; William E Connor |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 58 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-31 Completed Date: 2006-01-04 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: United States |
Other Details:
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Languages: eng Pagination: 865-72 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine, Oregon National Primate Research Center, Oregon Health and Science University, Portland, Oregon 97239-3098, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / metabolism* Electroretinography Erythrocytes / metabolism Fatty Acids, Omega-3* / blood Fatty Acids, Unsaturated / deficiency* Macaca mulatta / physiology* Retina / metabolism*, physiopathology Visual Acuity* alpha-Linolenic Acid / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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DK29930/DK/NIDDK NIH HHS; DK40935/DK/NIDDK NIH HHS; RR00163/RR/NCRR NIH HHS; RR00334/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 463-40-1/alpha-Linolenic Acid |
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