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Can placental histology establish the timing of meconium passage during labor?
MedLine Citation:
PMID:  21504416     Owner:  NLM     Status:  Publisher    
Objective. To evaluate the relation between duration of placental exposure to recently passed meconium in vivo and histologic evidence of meconium uptake by macrophages. Design. Retrospective cohort. Setting. University Hospital. Population. A total of 44 term deliveries of singleton infants with moderate or thick meconium had placental examination and documented timing of meconium appearance after membrane rupture. Methods. Placentas were examined to assess the extent of meconium uptake by macrophages based on location in the amniochorionic membranes, chorionic plate and umbilical cord, and the intensity of uptake, based on the number of macrophages/field. An arbitrary score of severity of uptake was also created by multiplying the intensity of meconium uptake (number of meconium-laden macrophages) by the extent in the three placental areas. Twenty cases of singleton term pregnancy with clear amniotic fluid throughout labor and at delivery were included as negative controls. Main outcome measures. Relation between interval of meconium exposure in vivo and uptake by macrophages. Results. The median interval from meconium appearance to delivery was 95minutes (range 10-510min). The median score of severity of meconium uptake was significantly higher than in the negative controls. There was no correlation between the interval of meconium appearance-to-delivery and score of severity of meconium uptake (p=0.76). Inflammatory lesions were present in 12/44 (27%) cases and vascular lesions in 11/44 (25%). Conclusion. Duration of placental exposure to meconium in vivo was not related to meconium uptake by macrophages where exposure was <8.5hours.
Maddalena Incerti; Anna Locatelli; Sara Consonni; Francesca Bono; Biagio E Leone; Alessandro Ghidini
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-19
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 The Authors AOGS© 2011 Nordic Federation of Societies of Obstetrics and Gynecology.
Department of Obstetrics and Gynecology Department of Pathology, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.
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