| Can permeability measurements add to blood volume measurements in differentiating tumefactive demyelinating lesions from high grade gliomas using perfusion CT? | |
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MedLine Citation:
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PMID: 19830525 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tumefactive demyelinating lesions (TDLs) can mimic a neoplasm on conventional imaging and may necessitate biopsy for diagnosis. The purpose of this study was to differentiate TDLs from high grade gliomas based on physiologic (permeability) and hemodynamic (blood volume) parameters using perfusion CT. Five patients who presented with tumefactive enhancing lesions on initial MRI that mimicked a neoplasm underwent perfusion CT. We compared the perfusion CT parameters of these patients with those of 24 patients with high grade gliomas. TDLs showed lower permeability surface area product (PS) (0.8 +/- 0.2 vs 2.4 +/- 1.4 ml/100 g/min, P-value 0.014) and lower cerebral blood volume (CBV) (1.0 +/- 0.2 vs 2.8 +/- 1.2 ml/100 g, P-value 0.006) as compared to high grade gliomas. TDLs show lower PS and CBV as compared to high grade gliomas, to which they can mimic on conventional MR imaging, due to lack of neoangiogenesis and vascular endothelial proliferation and hence perfusion CT can be used to differentiate the two entities. |
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Authors:
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Rajan Jain; Shehanaz Ellika; Norman L Lehman; Lisa Scarpace; Lonni R Schultz; Jack P Rock; Mark Rosenblum; Tom Mikkelsen |
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Publication Detail:
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Type: Journal Article Date: 2009-10-15 |
Journal Detail:
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Title: Journal of neuro-oncology Volume: 97 ISSN: 1573-7373 ISO Abbreviation: J. Neurooncol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309335 Medline TA: J Neurooncol Country: United States |
Other Details:
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Languages: eng Pagination: 383-8 Citation Subset: IM |
Affiliation:
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Division of Neuroradiology, Department of Radiology, Henry Ford Health System, 2799 West Grand Blvd, Detroit, MI 48202, USA. rajanj@rad.hfh.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biopsy Blood Volume / physiology* Blood Volume Determination / methods Brain Mapping Brain Neoplasms / pathology, physiopathology, radiography* Cerebrovascular Circulation / physiology Contrast Media Demyelinating Diseases / diagnosis*, physiopathology* Diagnosis, Differential Female Glioma / pathology, physiopathology, radiography* Humans Magnetic Resonance Imaging / methods Male Middle Aged Perfusion / methods Tomography, X-Ray Computed / methods* |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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