Document Detail

Can perioperative C-reactive protein and interleukin-6 levels predict atrial fibrillation after coronary artery bypass surgery?
MedLine Citation:
PMID:  18946567     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the relationship between proinflammatory cytokines, such as interleukin-6 (IL-6) and C-reactive protein (CRP) and atrial fibrillation after on-pump coronary artery bypass grafting (CABG). METHODS: Fifty-four patients with coronary artery disease undergoing elective CABG at the Mazandaran Medical University, Mazandaran, Iran were enrolled in our prospective study in the year 2007. Postoperatively, heart rate and rhythm were continuously monitored for 5 days. Fasting blood samples were taken from all patients to examine quantities of CRP and IL6 the day before surgery and on the second postoperative day in the intensive care unit. RESULTS: From 54 patients, 11 patients (20.4%) developed atrial fibrillation (AF) after CABG. The median age of patients with AF was 51.45 +/- 10.74 compared with 57.28 +/- 9.04 for patients with sinus rhythm (p=0.072). Cardioplegic time, cross clamp time, and pump time were higher in the AF group, but there was no significant difference between the 2 groups. Preoperative CRP and IL6 levels were higher in patients with AF. The CRP and IL6 increased after CABG in all patients, but it increased more in the AF group. CONCLUSION: There was a significant relationship between preoperative IL6 and AF in patients who underwent on-pump CABG, but there was no relationship between CRP and AF. Therefore, administration of glucocorticoids, which significantly reduce plasma levels of IL6 can reduce the incidence of AF after on-pump CABG.
Shervin Ziabakhsh-Tabari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Saudi medical journal     Volume:  29     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-23     Completed Date:  2009-01-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1429-31     Citation Subset:  IM    
Fatemeh Zahra Hospital of Sari, University of Medical Sciences, Mazandaran, Iran.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Atrial Fibrillation / blood*,  etiology,  prevention & control
Biological Markers / blood
C-Reactive Protein / metabolism*
Coronary Artery Bypass / adverse effects*
Interleukin-6 / blood*
Middle Aged
Prospective Studies
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biological Markers; 0/Interleukin-6; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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