| Can the pathophysiology of autism be explained by the nature of the discovered urine peptides? | |
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MedLine Citation:
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PMID: 12608733 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Opioid peptides derived from food proteins (exorphins) have been found in urine of autistic patients. Based on the work of several groups, we try to show that exorphins and serotonin uptake stimulating factors may explain many of the signs and symptoms seen in autistic disorders. The individual symptoms ought to be explainable by the properties and behavioural effects of the found peptides. The data presented form the basis of an autism model, where we suggest that exorphins and serotonin uptake modulators are key mediators for the development of autism. This may be due to a genetically based peptidase deficiency in at least two or more peptidases and, or of peptidase regulating proteins made manifest by a dietary overload of exorphin precursors such as by increased gut uptake. |
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Authors:
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K L Reichelt; A M Knivsberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Nutritional neuroscience Volume: 6 ISSN: 1028-415X ISO Abbreviation: Nutr Neurosci Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-02-28 Completed Date: 2003-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892202 Medline TA: Nutr Neurosci Country: England |
Other Details:
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Languages: eng Pagination: 19-28 Citation Subset: IM |
Affiliation:
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Institute of Pediatric Research, Univ of Oslo, Rikshospitalet, N-0027, Oslo, Norway. k.l.reichelt@klinmed.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Autistic Disorder / genetics, physiopathology*, urine* Brain Diseases / complications Diet Epilepsy / epidemiology Habituation, Psychophysiologic Humans Immunity Intestinal Diseases / complications Peptides / urine* Serotonin Agents Sleep Social Behavior Stereotyped Behavior |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 0/Serotonin Agents; 69989-30-6/exorphins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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