Document Detail

Can the pathophysiology of autism be explained by the nature of the discovered urine peptides?
MedLine Citation:
PMID:  12608733     Owner:  NLM     Status:  MEDLINE    
Opioid peptides derived from food proteins (exorphins) have been found in urine of autistic patients. Based on the work of several groups, we try to show that exorphins and serotonin uptake stimulating factors may explain many of the signs and symptoms seen in autistic disorders. The individual symptoms ought to be explainable by the properties and behavioural effects of the found peptides. The data presented form the basis of an autism model, where we suggest that exorphins and serotonin uptake modulators are key mediators for the development of autism. This may be due to a genetically based peptidase deficiency in at least two or more peptidases and, or of peptidase regulating proteins made manifest by a dietary overload of exorphin precursors such as by increased gut uptake.
K L Reichelt; A M Knivsberg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  6     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-02-28     Completed Date:  2003-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  England    
Other Details:
Languages:  eng     Pagination:  19-28     Citation Subset:  IM    
Institute of Pediatric Research, Univ of Oslo, Rikshospitalet, N-0027, Oslo, Norway.
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MeSH Terms
Autistic Disorder / genetics,  physiopathology*,  urine*
Brain Diseases / complications
Epilepsy / epidemiology
Habituation, Psychophysiologic
Intestinal Diseases / complications
Peptides / urine*
Serotonin Agents
Social Behavior
Stereotyped Behavior
Reg. No./Substance:
0/Peptides; 0/Serotonin Agents; 69989-30-6/exorphins

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