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Can pancreaticoduodenectomy performed at a comprehensive community cancer center have comparable results as major tertiary center?
MedLine Citation:
PMID:  22811844     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Pancreatic resection is a definitive treatment modality for pancreatic neoplasm. Pancreaticoduodenectomy (PD) is the primary procedure for tumor arising from head of pancreas. Prognosis is overwhelmingly poor despite adequate resection. We maintained a prospective database covering years 2001 to 2010. Outcome data is analyzed and compared with those from tertiary centers.
METHODS: Sixty-two patients with various histology were included. Pylorus preserving pancreatico-duodenectomy (PPPD), classic pancreaticoduodenectomy, and subtotal pancreatectomy were procedures performed. Three patients had portal venorrhaphy performed to obtain clinically negative margin. Forty six patients had malignancy on final pathologic analysis.
RESULTS: The average age of patients was 63. Mean preoperative CA19-9 for exocrine pancreatic malignancies was higher than for more benign lesions. There was a decrease in operative time during this period. Blood transfusion was uncommon. There was very few pancreatic leak among the patients. Two bile leaks were identified, one controlled with the drainage tube and the other one required repeat surgery. The primary reason for the prolonged hospitalization was gastric ileus. For patients without a gastrostomy tube, nasogastric tube was kept in until gastric ileus resolved. 30 days mortality rate was calculated at 4.8. Mean survival time during our follow up was 30.6 months. Comparing to published literature, present series' mortality, morbidity, and survival are similar. Five year survival was 39%.
CONCLUSION: Despite overall poor outcome for patients with pancreatic and biliary malignancies, we conclude that surgery can be performed in community hospitals with special interest in treating pancreatic disorder, offering patients equivalent survival and quality of life as those operated in tertiary centers.
Charles Cheng; David Duppler; Boguslawa Koczon Jaremko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of gastrointestinal oncology     Volume:  2     ISSN:  2219-679X     ISO Abbreviation:  J Gastrointest Oncol     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2012-07-19     Completed Date:  2012-08-23     Revised Date:  2013-05-30    
Medline Journal Info:
Nlm Unique ID:  101557751     Medline TA:  J Gastrointest Oncol     Country:  China    
Other Details:
Languages:  eng     Pagination:  143-50     Citation Subset:  -    
Appleton Medical Center, Fox Valley Surgical Associates, Appleton, Wisconsin, USA.
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