Document Detail


Can overeating induce conditioned taste avoidance in previously food restricted rats?
MedLine Citation:
PMID:  20035776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While feeding is rewarding, the feeling of satiation has been theorized to have a mixed affect. Using a food restriction model of overeating we examined whether bingeing was capable of supporting conditioned taste avoidance (CTA). Adult male Sprague-Dawley rats were maintained on either an ad lib (n=8) or restricted (50% of regular consumption; n=24) food access for 20 days. On Days 9, 14, and 19 all rats were given access to a novel saccharin solution in place of water, and two groups of food restricted rats were given access to either 100% of regular food consumption or ad lib food. Ad lib access in the restricted rats induced significant overeating on all three exposures. After all rats were returned to ad lib feeding, a 24h two-bottle saccharin/water choice test displayed significantly reduced saccharin consumption in the overeating rats, compared to those in the other 3 groups. To determine whether this avoidance was due to a learned association, a second experiment used a latent inhibition paradigm, familiarizing half the rats with the saccharin for 8 days prior to pairing it with overeating. Using the design of Experiment 1, with only the continuously ad lib and the restricted to ad lib feeding groups, it was found that the overeating-induced saccharin avoidance was attenuated by the pre-exposure. These results suggest that self-induced overeating is capable of supporting a learned avoidance of a novel solution suggestive of a conditioned satiety or taste avoidance.
Authors:
Amanda Hertel; Roelof Eikelboom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-24
Journal Detail:
Title:  Physiology & behavior     Volume:  99     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-05-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  482-6     Citation Subset:  IM    
Copyright Information:
(c) 2009 Elsevier Inc. All rights reserved.
Affiliation:
Department of Psychology, Wilfrid Laurier University, 75 University Ave West, Waterloo ON, Canada.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Avoidance Learning / drug effects,  physiology*
Drinking
Eating / physiology
Food Deprivation / physiology*
Food Preferences / physiology
Hyperphagia / physiopathology*
Male
Random Allocation
Rats
Rats, Sprague-Dawley
Saccharin / administration & dosage
Sweetening Agents / administration & dosage
Taste / drug effects,  physiology*
Time Factors
Chemical
Reg. No./Substance:
0/Sweetening Agents; 81-07-2/Saccharin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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