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Can the occurrence of gastrointestinal bleeding in nonpulsatile left ventricular assist device patients provide clues for the reversal of arteriosclerosis?
MedLine Citation:
PMID:  22062216     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
This article is written not only to explore the deleterious effects of nonpulsatile flow (namely, gastrointestinal [GI] bleeding), but also to propose the novel concept that deliberate induction of nonpulsatile flow might be harnessed to produce beneficial remodeling in arteriosclerotic arteries. Continuous-flow left ventricular assist devices have proven their efficacy in the treatment of end-stage heart disease. They are a reliable option in bridge-to-transplant and destination therapy. An enigmatic consequence of this therapy has been occult GI bleeding.
Authors:
Louis H Stein; John A Elefteriades
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology clinics     Volume:  29     ISSN:  1558-2264     ISO Abbreviation:  Cardiol Clin     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8300331     Medline TA:  Cardiol Clin     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  641-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Affiliation:
Section of Cardiac Surgery, Yale University School of Medicine, Boardman 2, 333 Cedar Street, New Haven, CT 06510, USA.
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