Document Detail

Can noninvasive imaging accurately depict intracranial aneurysms? A systematic review.
MedLine Citation:
PMID:  11058629     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To perform a systematic review to determine the accuracy of computed tomographic (CT) angiography, magnetic resonance (MR) angiography, and transcranial Doppler ultrasonography (US) in depicting intracranial aneurysms. MATERIALS AND METHODS: A 1988-1998 literature search for studies with 10 or more subjects in which noninvasive imaging was compared with angiography was undertaken. Studies meeting initial criteria were evaluated by using intrinsically weighted standardized assessment to determine suitability for inclusion. Studies scoring greater than 50% were included. RESULTS: Of 103 studies that met initial criteria, 38 scored greater than 50%. CT angiography and MR angiography had accuracies per aneurysm of 89% (95% CI: 87%, 91%) and 90% (95% CI: 87%, 92%), respectively. For US, data were scanty and accuracy was lower, although the CIs overlapped those of CT angiography and MR angiography. Sensitivity was greater for detection of aneurysms larger than 3 mm than for detection of aneurysms 3 mm or smaller-for CT angiography, 96% (95% CI: 94%, 98%) versus 61% (95% CI: 51%, 70%), and for MR angiography, 94% (95% CI: 90%, 97%) versus 38% (95% CI: 25%, 53%). Diagnostic accuracy was similar for anterior and posterior circulation aneurysms. CONCLUSION: CT angiography and MR angiography depicted aneurysms with an accuracy of about 90%. Most studies were performed in populations with high aneurysm prevalence, which may have introduced bias toward noninvasive examinations.
P M White; J M Wardlaw; V Easton
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  217     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-13     Completed Date:  2000-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  361-70     Citation Subset:  AIM; IM    
Depts of Neurosurgery and Neuroradiology, Institute of Neurological Sciences, Southern General Hosp, Glasgow, Scotland.
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MeSH Terms
Cerebral Angiography
Intracranial Aneurysm / diagnosis*
Magnetic Resonance Angiography*
Predictive Value of Tests
Sensitivity and Specificity
Tomography, X-Ray Computed*
Ultrasonography, Doppler, Transcranial*
Comment In:
Radiology. 2000 Nov;217(2):319-20   [PMID:  11058624 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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