| Can a nine-month regimen be used to treat isoniazid resistant tuberculosis diagnosed after standard treatment is started? | |
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MedLine Citation:
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PMID: 11243745 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: National tuberculosis treatment guidelines suggest a regimen of 2RZE/10RE for the treatment of isoniazid resistant organisms. A retrospective clinical study of all patients treated for non-MDR-TB isoniazid-resistant organisms was undertaken. METHODS: A continuous database of the patients treated between 1978-1999 inclusive was examined to determine the regimens used and the outcome of treatment for such patients. RESULTS: Thirty-seven patients were identified. Eighteen had regimens of greater than 9 months, 19 had regimens of 9 months or less. No relapses occurred in those cases treated with a regimen of 2RZE/7RE during 12 months' minimum follow-up. CONCLUSIONS: A regimen of 2RZE/7RE may be possible for the treatment of isoniazid-resistant organisms if given either under close supervision or as a formally supervised regimen. Larger clinical studies or a controlled clinical trial are needed to confirm these initial findings. |
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Authors:
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L P Ormerod; N Horsfield; R M Green |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of infection Volume: 42 ISSN: 0163-4453 ISO Abbreviation: J. Infect. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-03-13 Completed Date: 2001-09-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7908424 Medline TA: J Infect Country: England |
Other Details:
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Languages: eng Pagination: 1-3 Citation Subset: IM |
Copyright Information:
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Copyright 2001 The British Infection Society. |
Affiliation:
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Chest Clinic, Blackburn Royal Infirmary, Blackburn, Lancs, BB2 3LR, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antitubercular Agents / administration & dosage*, therapeutic use Drug Administration Schedule Drug Resistance, Microbial Female Humans Isoniazid / administration & dosage*, therapeutic use Male Middle Aged Retrospective Studies Time Factors Treatment Outcome Tuberculosis / drug therapy* Tuberculosis, Multidrug-Resistant / diagnosis, drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antitubercular Agents; 54-85-3/Isoniazid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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