Document Detail

Can a nine-month regimen be used to treat isoniazid resistant tuberculosis diagnosed after standard treatment is started?
MedLine Citation:
PMID:  11243745     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: National tuberculosis treatment guidelines suggest a regimen of 2RZE/10RE for the treatment of isoniazid resistant organisms. A retrospective clinical study of all patients treated for non-MDR-TB isoniazid-resistant organisms was undertaken. METHODS: A continuous database of the patients treated between 1978-1999 inclusive was examined to determine the regimens used and the outcome of treatment for such patients. RESULTS: Thirty-seven patients were identified. Eighteen had regimens of greater than 9 months, 19 had regimens of 9 months or less. No relapses occurred in those cases treated with a regimen of 2RZE/7RE during 12 months' minimum follow-up. CONCLUSIONS: A regimen of 2RZE/7RE may be possible for the treatment of isoniazid-resistant organisms if given either under close supervision or as a formally supervised regimen. Larger clinical studies or a controlled clinical trial are needed to confirm these initial findings.
L P Ormerod; N Horsfield; R M Green
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of infection     Volume:  42     ISSN:  0163-4453     ISO Abbreviation:  J. Infect.     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-03-13     Completed Date:  2001-09-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7908424     Medline TA:  J Infect     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-3     Citation Subset:  IM    
Copyright Information:
Copyright 2001 The British Infection Society.
Chest Clinic, Blackburn Royal Infirmary, Blackburn, Lancs, BB2 3LR, UK.
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MeSH Terms
Antitubercular Agents / administration & dosage*,  therapeutic use
Drug Administration Schedule
Drug Resistance, Microbial
Isoniazid / administration & dosage*,  therapeutic use
Middle Aged
Retrospective Studies
Time Factors
Treatment Outcome
Tuberculosis / drug therapy*
Tuberculosis, Multidrug-Resistant / diagnosis,  drug therapy
Reg. No./Substance:
0/Antitubercular Agents; 54-85-3/Isoniazid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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