Document Detail

Can neuroimaging techniques identify individuals at risk of developing Alzheimer's disease?
MedLine Citation:
PMID:  9549589     Owner:  NLM     Status:  MEDLINE    
Recent studies indicate that neuroimaging techniques such as magnetic resonance imaging, positron emission tomography, and single-photon emission computed tomography can accurately differentiate patients with Alzheimer's disease (AD) from elderly controls. This report reviews the results of neuroimaging studies of two at-risk populations: subjects with the epsilon 4 allele of the apolipoprotein E and those with mild cognitive impairment. The results of the work published to date indicate that the presence of the epsilon 4 allele is a risk factor for AD and that its predictive validity can be enhanced by neuropsychological and/or neuroimaging evaluation. The results also show that patients with mild cognitive impairment display a number of structural and functional imaging abnormalities that are more pronounced in the temporal and parietal lobes. We suggest that the use of neuroimaging techniques can improve the detection of subjects early in the course of AD, although the sensitivity and the specificity of this approach still await a more detailed prospective evaluation.
C M Bottino; O P Almeida
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  International psychogeriatrics / IPA     Volume:  9     ISSN:  1041-6102     ISO Abbreviation:  Int Psychogeriatr     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-07-13     Completed Date:  1998-07-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9007918     Medline TA:  Int Psychogeriatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  389-403     Citation Subset:  IM    
Institute and Department of Psychiatry, Faculty of Medicine, University of São Paulo, Brazil.
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MeSH Terms
Alzheimer Disease / complications,  genetics,  radiography*,  radionuclide imaging
Apolipoproteins E / genetics
Cerebral Cortex / radiography*,  radionuclide imaging
Cognition Disorders / etiology,  radiography*
Disease Progression
Disease Susceptibility
Magnetic Resonance Imaging
Neuropsychological Tests
Risk Factors
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
0/Apolipoproteins E

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