Document Detail

Can neonatal TSH screening reflect trends in population iodine intake?
MedLine Citation:
PMID:  18651804     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The distribution of neonatal blood thyroid-stimulating hormone (TSH) concentrations has been used as an index reflecting population dietary iodine intake, with higher concentrations being indicative of lower iodine intake. We examined this distribution in neonates born in Ireland, where the pregnant population has shown a recent decline in urinary iodine (UI) excretion. Our objectives were to determine if any alteration was observed in the percentage of values > 5.0 mIU/L and whether a trend in neonatal blood TSH was apparent. METHODS: Samples drawn from the National Neonatal Screening Programme were assessed during the years 1995-2006 from winter (January n = 35,079) and summer (August n = 37,940) months, respectively, in view of the known seasonal variation in Irish dietary iodine intake. RESULTS: Apart from the first years studied (1995-1996), the proportion of individual blood TSH values >5.0 mIU/L did not exceed 3%, a value believed to be indicative of iodine deficiency. A significant declining trend in the proportion of blood TSH >5.0 mIU/L was observed in subsequent years (p < 0.01). While excluding severe iodine deficiency, these analyses failed to detect the slight but highly significant (p < 0.001) tendency toward increasing blood TSH within the 0-5.0 mIU/L interval in the study population between 1999 and 2006, which was greater in summer than in winter months (p < 0.001). CONCLUSIONS: These data support a link between fetal thyroid function and a fall in maternal iodine intake. While the findings of the proportion of blood TSH values >5.0 mIU/L exclude severe maternal or fetal iodine deficiency, a trend toward increasing TSH may provide an early indication of impending iodine deficiency. The findings assume greater importance in the context of declining UI reported from many developed countries even where the proportion of blood TSH values >5.0 mIU/L is <3%, thus excluding severe maternal and fetal iodine deficiency.
Robert Burns; Philip D Mayne; Colm O'Herlihy; Derek F Smith; Mary Higgins; Anthony Staines; Peter P A Smyth
Related Documents :
19843064 - Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to prop...
12907094 - Maternal hypothyroidism may affect fetal growth and neonatal thyroid function.
18063104 - Thyroid disease in pregnancy.
24770264 - Clinical significance of growth restriction in pregnancies with gastroschisis.
19026874 - The effect of tooth bleaching on substance p expression in human dental pulp.
7956994 - No changes during pregnancy in the net cost of cycling exercise.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  18     ISSN:  1050-7256     ISO Abbreviation:  Thyroid     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  883-8     Citation Subset:  IM    
UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine and Medical Science, University College Dublin, Dublin 4, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Congenital Hypothyroidism / diagnosis
Deficiency Diseases / epidemiology
Infant, Newborn
Iodine / deficiency*,  urine
Ireland / epidemiology
Neonatal Screening*
Thyrotropin / blood*
Reg. No./Substance:
7553-56-2/Iodine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Potent inhibition of thyroid cancer cells by the MEK inhibitor PD0325901 and its potentiation by sup...
Next Document:  Morphologic characteristics of Chernobyl-related childhood papillary thyroid carcinomas are independ...