Document Detail

Can mild bronchospasm reduce gastroesophageal reflux?
MedLine Citation:
PMID:  2912356     Owner:  NLM     Status:  MEDLINE    
During attacks of asthma, changes in the transdiaphragmatic pressure gradient may impair the antireflux barrier and provoke gastroesophageal reflux (GER). If GER triggers asthma and asthma causes GER, a vicious circle could arise with an increase in the severity of asthma symptoms. The aim of this investigation was to determine whether postprandial reflux in asthmatics with GER disease is increased during histamine-induced bronchospasm and also if theophylline increases GER during provoked episodes of bronchospasm. Ten patients with chronic asthma and pathologic GER were challenged with either histamine or saline in randomized order with and without their regular dose of oral slow-release theophylline. FEV1 was recorded at regular intervals during the hour of provocation, and acid reflux (pH less than 4) was monitored by antimony pH electrodes in the esophagus. GER was not more pronounced during the provoked bronchospasm period irrespective of theophylline treatment or not. It seems unlikely that mild bronchospasm provokes reflux in patients with asthma and GER. It would appear that mild bronchospasm is rather protective against gastroesophageal reflux.
T K Ekström; L I Tibbling
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  139     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-02-15     Completed Date:  1989-02-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  52-5     Citation Subset:  AIM; IM    
Department of Lung Medicine, University Hospital, Linköping, Sweden.
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MeSH Terms
Asthma / complications,  drug therapy,  physiopathology*
Bronchial Provocation Tests
Esophagogastric Junction / drug effects,  physiopathology
Forced Expiratory Volume
Gastric Acid / secretion
Gastroesophageal Reflux / complications,  physiopathology*
Histamine / pharmacology
Middle Aged
Theophylline / therapeutic use
Reg. No./Substance:
51-45-6/Histamine; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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