Document Detail

Can mean platelet volume determine the severity of liver fibrosis or inflammation in patients with chronic hepatitis B?
MedLine Citation:
PMID:  23325286     Owner:  NLM     Status:  MEDLINE    
AIMS: We aimed to determine whether mean platelet volume (MPV) is one of the variables that determine the severity of liver fibrosis and inflammation.
MATERIALS AND METHODS: Patients with chronic hepatitis B virus (HBV) infection were divided into two groups: patients with fibrosis scores of 0-3 and 4-6 and patients with histologic activity index scores of 0-9 and 10-18 (according to the Ishak Scoring System). The independent variables determining the severity of liver fibrosis and inflammation were investigated.
RESULTS: Two hundred and thirty-eight patients were included in this retrospective study. The fibrosis scores of 29 patients (12.2%) were higher than 3. The independent variables that determined the severity of the fibrosis score were a high level of serum γ-glutamyl transferase and a low blood platelet count (odds ratio and P values were 1.016 and 0.004 for γ-glutamyl transferase, and 0.986 and 0.002 for blood platelet count). The histologic activity indexes of 38 patients (16%) were higher than 9. The independent variables determining the severity of liver inflammation were serum HBV DNA, γ-glutamyl transferase, and globulin levels and the MPV [odds ratio and P values were, respectively, 0.1001 and 0.046 for HBV DNA (×10); 1.016 and 0.004 for γ-glutamyl transferase; 2.247 and 0.039 for globulin; and 1.488 and 0.004 for the MPV]. The sensitivity, specificity, and positive predictive value and negative predictive value of the model predicting the severity of liver inflammation were 60.5, 83, 40.3, and 91.7%, respectively (area under the receiver-operating characteristic curve=0.775, P=0.0001).
CONCLUSION: MPV may provide useful information to predict the degree of liver inflammation along with other markers.
Bahadir Ceylan; Muzaffer Fincanci; Cem Yardimci; Gülhan Eren; Ümit Tözalgan; Cüneyt Müderrisoğlu; Esra Paşaoğlu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of gastroenterology & hepatology     Volume:  25     ISSN:  1473-5687     ISO Abbreviation:  Eur J Gastroenterol Hepatol     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-03-29     Completed Date:  2013-09-25     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  9000874     Medline TA:  Eur J Gastroenterol Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  606-12     Citation Subset:  IM    
Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Bezmialem Vakif University, Istanbul, Turkey.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Blood Platelets / pathology*
Case-Control Studies
Cell Size
Hepatitis B, Chronic / blood,  complications*,  diagnosis,  pathology
Liver / pathology
Liver Cirrhosis / blood,  diagnosis,  virology*
Middle Aged
Platelet Count
Predictive Value of Tests
Severity of Illness Index
Young Adult
gamma-Glutamyltransferase / blood
Reg. No./Substance:
0/Biological Markers; EC
Comment In:
Eur J Gastroenterol Hepatol. 2013 Nov;25(11):1364   [PMID:  23652912 ]

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