Document Detail

Can levels of interleukins and matrix metalloproteinases in the amniotic fluid predict postnatal bowel function in fetuses with gastroschisis?
MedLine Citation:
PMID:  16338312     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to determine whether interleukin or matrix metalloproteinase (MMP) levels in the amniotic fluid can predict the postnatal condition of the bowel in fetuses with gastroschisis (GS). METHODS: Eleven pregnant women with a fetus with GS underwent amniocentesis. Levels of IL-1alpha, IL-1beta, and IL-6 were measured in 10 of 11 specimens, and MMP-1, MMP-3, and MMP-8 levels were measured in 7 of 11 specimens. Neonates who tolerated complete oral feeding within 21 days were considered to have good bowel status (GS/good: n = 4, 4 in interleukin study or 3 in MMP study); those who did not were considered to have poor bowel status (GS/poor: n =7, 6 in interleukin study or 4 in MMP study). Seventy-eight women undergoing amniocentesis for other reasons served as controls. RESULTS: Interleukin-1 levels were considerably lower in the pregnancies complicated by GS than in controls. Matrix metalloproteinases 3 and 8 levels were significantly higher in the GS pregnancies than in controls. Neonates with poor bowel status had higher MMP-3 and MMP-8 levels than those with good bowel status. CONCLUSION: Amniotic fluid MMP-3 and MMP-8 levels may prove useful to assess the condition of the bowel in fetuses with GS.
Guenter Fasching; Martin Haeusler; Johannes Mayr; Guenther Schimpl; Josef Haas; Peter Puerstner
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of pediatric surgery     Volume:  40     ISSN:  1531-5037     ISO Abbreviation:  J. Pediatr. Surg.     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-12     Completed Date:  2006-07-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052631     Medline TA:  J Pediatr Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1887-91     Citation Subset:  IM    
Department of Pediatric Surgery, Medical University of Graz, A-8036 Graz, Austria.
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MeSH Terms
Amniotic Fluid / chemistry*
Biological Markers / analysis
Collagen / metabolism
Gastroschisis / complications,  pathology*
Infant, Newborn
Interleukin-1 / analysis*
Intestines / physiology*
Matrix Metalloproteinase 3 / analysis*
Matrix Metalloproteinase 8 / analysis*
Predictive Value of Tests
Pregnancy Complications*
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-1; 9007-34-5/Collagen; EC Metalloproteinase 3; EC Metalloproteinase 8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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