Document Detail

Can the joint effect of ternary mixtures be predicted from binary mixture toxicity results?
MedLine Citation:
PMID:  22542295     Owner:  NLM     Status:  Publisher    
The joint effect of the majority of chemical mixtures can be predicted using the reference model of Concentration Addition (CA). It becomes a challenge, however, when the mixtures include chemicals that synergise or antagonise the effect of each other. In this study we examine if the deviation from CA of seven ternary mixtures of interacting chemicals can be predicted from knowledge of the binary mixture responses involved. We hypothesise that the strongest interactions will take place in the binary mixtures and that the size of the ternary mixture response can be predicted from knowledge of the binary interactions. The hypotheses were tested using a stepwise modelling approach of incorporating the information held in binary mixtures into a ternary mixture model, and comparing the model predictions with observed ternary mixture toxicity data derived from studies of interacting chemical mixtures on the floating plant Lemna minor and the bacteria Vibrio fischeri. The results showed that for both the antagonistic and the synergistic ternary mixtures the ternary model predictions were superior to the conventional CA reference model and provided robust estimations of the size of the experimentally derived ternary mixture toxicity effects.
Nina Cedergreen; Helle Sørensen; Claus Svendsen
Related Documents :
12500865 - Comment on "competition for consciousness among visual events: the psychophysics of ree...
7576345 - New statements on the gaia theory.
17995385 - Classical world arising out of quantum physics under the restriction of coarse-grained ...
2587685 - The contribution of hartmann's adaptational theory to psychoanalysis, with special refe...
19689205 - Microscopy-based hts examines the mechanism of stress f-actin fiber disruption by cytoc...
22404495 - In vivo phycocyanin flourometry as a potential rapid screening tool for predicting elev...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-27
Journal Detail:
Title:  The Science of the total environment     Volume:  -     ISSN:  1879-1026     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0330500     Medline TA:  Sci Total Environ     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Basic Sciences and Environment, Faculty of Life Science, University of Copenhagen, Thorvaldsensvej 40, 1871 Frederiksberg C., Denmark.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Carcinogenic polycyclic aromatic hydrocarbons in umbilical cord blood of human neonates from Guiyu, ...
Next Document:  Microbiological quality indicators in waters of dairy farms: Detection of pathogens by PCR in real t...