| Can ischemia-modified albumin be a valuable indicator of tissue ischemia in polycythemia vera? | |
| | |
MedLine Citation:
|
PMID: 20557673 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The red cell expansion in polycythemia vera (PV) causes hyperviscosity affecting blood flow, which plays a major role in the pathogenesis of both microcirculatory disturbances and ultimately thromboses. Ischemia-modified albumin (IMA) is produced during an ischemic states and is present in blood in early and easily detectable levels. This study investigated whether IMA is a useful adjunct in the determination of ischemia in patients with PV, prior to them exhibiting clinical evidence of thrombotic complications. Blood IMA levels were determined in 20 PV patients and in 20 healthy individuals using a method described by Bar-Or. Mean IMA levels in the PV group were significantly higher than those of the control group (P<0.05). At the optimum cutoff point (0.193 absorbance units), the sensitivity and specificity of IMA were 80 and 100% to ischemia, respectively. In conclusion, IMA may be a valuable biochemical marker in predicting tissue ischemia in PV before the signs of vascular disturbances occur. |
| | |
Authors:
|
S Caner Karahan; Mehmet Sonmez; Fatma Saglam; Ahmet Mentese; Nergiz Erkut; Murat Topbas; Muge Kopuz; Umit Cobanoglu |
Related Documents
:
|
1929893 - Cerebrovascular instability in a subset of patients with stroke and transient ischemic ... 3766903 - Hypoxic-ischemic brain damage and cerebral blood flow changes in young rabbits. 622233 - Blood group incompatibility and cervical hostility in relation to sterility. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hematology (Amsterdam, Netherlands) Volume: 15 ISSN: 1607-8454 ISO Abbreviation: Hematology Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-06-18 Completed Date: 2010-10-14 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9708388 Medline TA: Hematology Country: England |
Other Details:
|
Languages: eng Pagination: 151-6 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, School of Medicine, Karadeniz Technical University, Trabzon, Turkey. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biological Markers
/
blood Female Humans Ischemia / blood*, pathology Male Middle Aged Polycythemia Vera / blood*, pathology Serum Albumin / metabolism* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Serum Albumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Gossypol exerts its cytotoxic effect on HL-60 leukemic cell line via decreasing activity of protein ...
Next Document: CD56-positive diffuse large B-cell lymphoma: possible association with extranodal involvement and bc...