| Can iron be teratogenic? | |
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MedLine Citation:
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PMID: 20024603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Several kinds of evidence indicate that elevated iron during the 3-8 week embryonic (organogenesis) period of human gestation may be teratogenic. (1) In the embryonic period, the natural maternal absorption of food iron is 30% below the estimated daily iron loss. (2) As compared with maternal serum, embryonic fetal coelomic fluid contains only one-fourth as much iron but nearly six times the quantity of the iron withholding protein, ferritin. (3) In the embryonic period, intraplacental oxygen pressure is 2-3 times lower than in the subsequent fetal growth period. (4) Iron is a strong inducer of emesis which peaks in the embryonic period. (5) In a murine gestation model, iron was neurotoxic at a sharp peak of 8-9 days. Thus it would be prudent, in human pregnancy, to delay any needed iron supplementation until the embryonic period has been completed. |
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Authors:
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E D Weinberg |
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Publication Detail:
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Type: Journal Article Date: 2009-12-19 |
Journal Detail:
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Title: Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine Volume: 23 ISSN: 1572-8773 ISO Abbreviation: Biometals Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-10 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9208478 Medline TA: Biometals Country: Netherlands |
Other Details:
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Languages: eng Pagination: 181-4 Citation Subset: IM |
Affiliation:
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Department of Biology & Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA. eweinber@Indiana.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Supplements / adverse effects Embryo, Mammalian / drug effects* Female Gestational Age Humans Intestinal Absorption / physiology Iron / pharmacology* Maternal Exposure Pregnancy Teratogens / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Teratogens; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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