Document Detail

Can iron be teratogenic?
MedLine Citation:
PMID:  20024603     Owner:  NLM     Status:  MEDLINE    
Several kinds of evidence indicate that elevated iron during the 3-8 week embryonic (organogenesis) period of human gestation may be teratogenic. (1) In the embryonic period, the natural maternal absorption of food iron is 30% below the estimated daily iron loss. (2) As compared with maternal serum, embryonic fetal coelomic fluid contains only one-fourth as much iron but nearly six times the quantity of the iron withholding protein, ferritin. (3) In the embryonic period, intraplacental oxygen pressure is 2-3 times lower than in the subsequent fetal growth period. (4) Iron is a strong inducer of emesis which peaks in the embryonic period. (5) In a murine gestation model, iron was neurotoxic at a sharp peak of 8-9 days. Thus it would be prudent, in human pregnancy, to delay any needed iron supplementation until the embryonic period has been completed.
E D Weinberg
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Publication Detail:
Type:  Journal Article     Date:  2009-12-19
Journal Detail:
Title:  Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine     Volume:  23     ISSN:  1572-8773     ISO Abbreviation:  Biometals     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-10     Completed Date:  2010-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9208478     Medline TA:  Biometals     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  181-4     Citation Subset:  IM    
Department of Biology & Program in Medical Sciences, Indiana University, Bloomington, IN 47405, USA.
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MeSH Terms
Dietary Supplements / adverse effects
Embryo, Mammalian / drug effects*
Gestational Age
Intestinal Absorption / physiology
Iron / pharmacology*
Maternal Exposure
Teratogens / pharmacology*
Reg. No./Substance:
0/Teratogens; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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