Document Detail

Can intraoperative thrombolytic therapy assist with the management of acute limb ischemia?
MedLine Citation:
PMID:  19298936     Owner:  NLM     Status:  MEDLINE    
Catheter-directed thrombolytic therapy is a well-accepted treatment modality for acute arterial and graft occlusion, but intraoperative use of plasminogen activators as an adjunct to operative thrombectomy or thromboembolectomy is frequently overlooked by vascular surgeons. Evidence exists that intraoperative intraarterial infusion of lytic agents is safe and is accompanied by breakdown of distal thrombus. This article describes the rationale for intraoperative thrombolysis, reviews the evidence supporting its use, and suggests several technical approaches to incorporating lytic therapy intraoperatively.
Anthony J Comerota; Ramandeep Sidhu
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in vascular surgery     Volume:  22     ISSN:  1558-4518     ISO Abbreviation:  Semin Vasc Surg     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-20     Completed Date:  2009-09-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8809602     Medline TA:  Semin Vasc Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Jobst Vascular Center, The Toledo Hospital, Toledo, OH 43606, USA.
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MeSH Terms
Acute Disease
Balloon Dilatation
Combined Modality Therapy
Extremities / blood supply*
Fibrinolytic Agents / administration & dosage*,  adverse effects
Intraoperative Care
Ischemia / drug therapy,  radiography,  surgery,  therapy*
Risk Assessment
Thrombectomy* / adverse effects
Thrombolytic Therapy* / adverse effects
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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