| Can intraoperative thrombolytic therapy assist with the management of acute limb ischemia? | |
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MedLine Citation:
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PMID: 19298936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Catheter-directed thrombolytic therapy is a well-accepted treatment modality for acute arterial and graft occlusion, but intraoperative use of plasminogen activators as an adjunct to operative thrombectomy or thromboembolectomy is frequently overlooked by vascular surgeons. Evidence exists that intraoperative intraarterial infusion of lytic agents is safe and is accompanied by breakdown of distal thrombus. This article describes the rationale for intraoperative thrombolysis, reviews the evidence supporting its use, and suggests several technical approaches to incorporating lytic therapy intraoperatively. |
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Authors:
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Anthony J Comerota; Ramandeep Sidhu |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in vascular surgery Volume: 22 ISSN: 1558-4518 ISO Abbreviation: Semin Vasc Surg Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-20 Completed Date: 2009-09-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8809602 Medline TA: Semin Vasc Surg Country: United States |
Other Details:
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Languages: eng Pagination: 47-51 Citation Subset: IM |
Affiliation:
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Jobst Vascular Center, The Toledo Hospital, Toledo, OH 43606, USA. marilyn.gravett@promedica.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Balloon Dilatation Combined Modality Therapy Embolectomy* Extremities / blood supply* Fibrinolytic Agents / administration & dosage*, adverse effects Humans Intraoperative Care Ischemia / drug therapy, radiography, surgery, therapy* Risk Assessment Thrombectomy* / adverse effects Thrombolytic Therapy* / adverse effects Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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