| Can inhaled corticosteroids prevent asthma exacerbations? | |
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MedLine Citation:
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PMID: 21045699 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: asthma exacerbations occur unpredictably, are a cause of morbidity and mortality, and contribute significantly to increased healthcare costs. Inhaled corticosteroids reduce exacerbations and improve quality of life. RECENT FINDINGS: the aetiopathology of asthma exacerbations is heterogeneous. Attempts to phenotype the heterogeneity of the pattern of airway inflammation by noninvasive monitoring of airway inflammation has identified a subgroup of patients with eosinophilic inflammation who are most likely to respond to steroid therapy. Strategies directed to normalize eosinophilic airway inflammation with corticosteroids have consistently led to a marked reduction in exacerbations. In contrast, their role in modulating the natural history of disease is less certain. SUMMARY: in the near future, improvements in our understanding of the mechanisms of exacerbations may identify therapeutic targets. While we await these developments, inhaled corticosteroids remain the first choice anti-inflammatory therapy for asthma. |
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Authors:
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Dhananjay Desai; Salman Siddiqui; Christopher Brightling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 17 ISSN: 1531-6971 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: 16-22 Citation Subset: IM |
Affiliation:
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Department of Infection, Inflammation and Immunity, Institute of Lung Health, University of Leicester, Leicester, UK. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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