Document Detail


Can an increased intake of metabolizable protein affect the periparturient relaxation in immunity against teladorsagia circumcincta in sheep?
MedLine Citation:
PMID:  10889359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Within the overall hypothesis that the periparturient relaxation of immunity (PPRI) to gastrointestinal parasites has a nutritional basis, we studied whether an increased intake of metabolizable protein (MP) could affect the expression of immunity to Teladorsagia (Ostertagia) circumcincta of twin-bearing and -rearing Greyface ewes. Two sets of iso-energetic diets were formulated to provide either 85% (L-) or 130% (H-) of the MP requirements during the last 6 weeks of pregnancy (-P) and the first 6 weeks of lactation (-L). Thirty ewes were allocated to LP or HP. Six ewes of each group were slaughtered after lambing (S(0)); the remaining 24 ewes of each group were allocated to either LL or HL, thus creating four treatment combinations during lactation (LP/LL, LP/HL, HP/LL and HP/HL; n=12). Six ewes of each treatment combination were slaughtered at Week 3 (S(3)) or at Week 6 (S(6)) in lactation. The HP ewes were heavier at lambing, produced heavier lambs, had lower faecal egg counts (FECs), a lower concentration of plasma pepsinogen, a higher concentration of plasma albumin during late pregnancy and more abomasal globule leukocytes (GLs) but similar worm burdens at S(0) compared to the LP ewes. The LP/HL and HP/HL ewes had a higher calculated milk production than the LP/LL and HP/LL ewes. FECs increased for each treatment combination during the first 3 weeks of lactation. This increase concurred with fewer abomasal GLs at S(3) compared to S(0). The LP/HL and HP/HL ewes had a higher proportion of immature worms and more abomasal GLs than the LP/LL and HP/LL ewes at S(6). The FECs continued to increase during the second 3 weeks of lactation for the LP/LL ewes only, which concurred with an elevated plasma pepsinogen concentration and an absence of abomasal GLs at S(6). The plasma pepsinogen concentration decreased rapidly for the LP/HL ewes during lactation. We conclude that an increased intake of MP could enhance the expression of immunity to T. circumcincta of twin-bearing and -rearing Greyface ewes.
Authors:
J G Houdijk; I Kyriazakis; F Jackson; J F Huntley; R L Coop
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary parasitology     Volume:  91     ISSN:  0304-4017     ISO Abbreviation:  Vet. Parasitol.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-09-05     Completed Date:  2000-09-05     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  7602745     Medline TA:  Vet Parasitol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  43-62     Citation Subset:  IM    
Affiliation:
Animal Nutrition and Health Department, Animal Biology Division, Scottish Agricultural College, Kings Buildings, EH9 3JG, Edinburgh, UK. j.houdijk@ed.sac.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animals
Blood Proteins / analysis
Dietary Proteins / administration & dosage,  pharmacology*
Energy Intake*
Female
Male
Ostertagia / immunology*
Ostertagiasis / immunology,  veterinary
Pepsinogen A / blood
Pregnancy
Pregnancy Complications, Parasitic / immunology*
Sheep
Sheep Diseases / immunology*
Chemical
Reg. No./Substance:
0/Blood Proteins; 0/Dietary Proteins; 9001-10-9/Pepsinogen A
Comments/Corrections
Erratum In:
Vet Parasitol 2000 Nov 10;93(2):175-8

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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