Document Detail

Can increased food intake improve psychosis? A brief review and hypothesis.
MedLine Citation:
PMID:  20021439     Owner:  NLM     Status:  MEDLINE    
Weight gain, diabetes, and changes in serum lipid profiles have been reported during treatment with typical and atypical antipsychotics. An association between diabetes and psychotic disorders was described long before the introduction of pharmacological agents for the treatment of schizophrenia. Several theories have been proposed to explain the baseline weight increase and metabolic disturbances in schizophrenia. Some studies suggest that increased food intake may improve psychotic symptoms in patients with schizophrenia but there have been conflicting results. Available clinical and basic research findings are discussed to evaluate the hypothesis that increased food intake may decrease sensitivity to dopamine signaling in the striatum. More research is needed to evaluate this potential link. However, basic animal research and evolutionary approaches can provide insights into metabolic disturbances associated with schizophrenia.
T Treuer; J Karagianis; V P Hoffmann
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current molecular pharmacology     Volume:  1     ISSN:  1874-4702     ISO Abbreviation:  Curr Mol Pharmacol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-02-24     Revised Date:  2011-12-29    
Medline Journal Info:
Nlm Unique ID:  101467997     Medline TA:  Curr Mol Pharmacol     Country:  United Arab Emirates    
Other Details:
Languages:  eng     Pagination:  270-2     Citation Subset:  IM    
Area Medical Center Vienna, Eli Lilly & Company, Austria.
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MeSH Terms
Dopamine / metabolism
Psychotic Disorders / therapy*
Schizophrenia / therapy

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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