Document Detail

Can gamma-glutamyltransferase be an additional marker of arterial stiffness?
MedLine Citation:
PMID:  17965490     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: It has been recently suggested that gamma-glutamyltransferase (GGT) is independently associated with cardiovascular mortality and atherosclerosis, so the present study evaluated whether GGT is an additional marker of arterial stiffness, independent of other risk factors, in screening cohorts. METHODS AND RESULTS: The 1,387 individuals (741 men, 646 women) who underwent brachial - ankle pulse wave velocity (baPWV) measurement had their serum levels of GGT, creatinine, uric acid, C-reactive protein, lipids, fasting glucose and insulin, and their hepatitis profiles checked. There were statistically significant increments of baPWV according to quartile of GGT, which was statistically significant in women, but not in men. In logistic regression analysis, age, diabetes mellitus, GGT, heart rate, history of hypertension, triglyceride, and systolic blood pressure were significant variables that influenced increased pulse wave velocity (PWV). After age-and blood pressure-adjustment, GGT, homeostatic model assessment-insulin resistance, heart rate, history of hypertension, and metabolic syndrome were significant variables in men, and in women metabolic syndrome and history of hypertension were significant contributors to increased PWV. CONCLUSION: The present study results suggest that serum GGT may be an additional marker of arterial stiffness, especially in men, though the relationship with arterial stiffness was very weak. Further studies are needed to elucidate the mechanism of GGT's contribution to arteriosclerosis and to confirm the current results.
Sang Heon Song; Ihm Soo Kwak; Yun Jin Kim; Seong-Jang Kim; Soo Bong Lee; Dong Won Lee; Bong Eun Lee
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  71     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1715-20     Citation Subset:  IM    
Department of Internal Medicine, Pusan National University Hospital, Ami-dong, Seo-gu, Busan, Republic of Korea.
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MeSH Terms
Age Factors
Arteries / physiopathology*
Arteriosclerosis / blood*,  diagnosis*
Biological Markers / blood
Blood Pressure / physiology
Brachial Artery / physiopathology
Middle Aged
Regional Blood Flow / physiology
Regression Analysis
Risk Factors
Sex Factors
gamma-Glutamyltransferase / blood*
Reg. No./Substance:
0/Biological Markers; EC

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