| Can first cycle CBCs predict older patients at very low risk of neutropenia during further chemotherapy? | |
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MedLine Citation:
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PMID: 20685130 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Elderly cancer patients with normal complete blood cell counts (CBCs) during the first course of (some types of) chemotherapy might be unlikely to experience grade 4 neutropenia during subsequent cycles. In this case, further weekly CBCs might be avoided. We used data of 223 cancer patients aged 70+ who were included in the CRASH (Chemotherapy Risk Assessment Score for High-age patients) trial between 2003 and 2007 in 7 cancer practices in the US. First cycle CBC values were compared to subsequent cycles. MAX2-score was used as a measure for toxicity of the chemotherapy regimen. Sixty-two patients (28%) experienced grade 4 neutropenia during subsequent cycles. Among patients who received chemotherapy with a MAX2-score lower than 0.20, only 4.6% of those without neutropenia during the first cycle experienced grade 4 neutropenia during subsequent cycles. Weekly CBC might be avoided in these patients receiving chemotherapy. Future prospective studies should confirm these results. |
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Authors:
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Maryska L G Janssen-Heijnen; Martine Extermann; Ivette E Boler |
Publication Detail:
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Type: Journal Article Date: 2010-08-03 |
Journal Detail:
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Title: Critical reviews in oncology/hematology Volume: 79 ISSN: 1879-0461 ISO Abbreviation: Crit. Rev. Oncol. Hematol. Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8916049 Medline TA: Crit Rev Oncol Hematol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 43-50 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Eindhoven Cancer Registry, Department of Research, Eindhoven, The Netherlands; Erasmus University Medical Centre, Department of Public Health, Rotterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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