Document Detail

Can expression of CD45RO, a T-cell surface molecule, be used to detect congenital infection?
MedLine Citation:
PMID:  7910277     Owner:  NLM     Status:  MEDLINE    
Exclusion or confirmation of congenital infection can be difficult in newborn infants. The presence of an infective organism in a fetus leads to activation of fetal T lymphocytes. We have examined expression of isoforms of a T-cell surface molecule, CD45RO, in 119 infants, 8 of whom had an intrauterine infection diagnosed antenatally. CD45RO was expressed on fewer than 10% of T cells in control infants and on more than 17% of T cells from infants with known infection (p < 0.006). This method allows screening of infants for infection by a range of organisms as a cause of their infection.
C Michie; D Harvey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  343     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1994 May 
Date Detail:
Created Date:  1994-06-16     Completed Date:  1994-06-16     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1259-60     Citation Subset:  AIM; IM    
Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, London, UK.
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MeSH Terms
Antigens, CD45 / blood*
Fetal Blood
Flow Cytometry
Infant, Newborn
Infection / blood,  congenital*
Reg. No./Substance:
EC, CD45
Comment In:
Lancet. 1994 Jul 9;344(8915):135   [PMID:  7912375 ]
Lancet. 1994 Jul 9;344(8915):135-6   [PMID:  7912376 ]

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