Document Detail

Can etomidate cause an Addisonian crisis?
MedLine Citation:
PMID:  3788439     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to assess if it could have been possible to discover the side effects of etomidate by infusion in an earlier phase of its introduction on the market, using the routine parameters of everyday anesthesiological practice. The study was undertaken in twelve patients scheduled for major abdominal vascular surgery. The effect of etomidate-fentanyl and air anesthesia was compared with the effects of neurolept anesthesia. Arterial blood-pressure, central venous blood pressure, pulse rate, peripheral and central body temperature were recorded continuously. Blood samples were taken every two hours during anesthesia for the estimation of arterial blood gases, cortisol, sodium, potassium and chloride. Significant differences were found mainly for the peripheral-, core temperature difference, the cumulative sodium and cumulative fluid balance from which the diagnosis addisonian crisis could have been made. There were also differences in the incidence of early and late complications and in the recovery rate of the patients after etomidate infusions.
M P Boidin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta anaesthesiologica Belgica     Volume:  37     ISSN:  0001-5164     ISO Abbreviation:  Acta Anaesthesiol Belg     Publication Date:  1986  
Date Detail:
Created Date:  1987-01-02     Completed Date:  1987-01-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0421022     Medline TA:  Acta Anaesthesiol Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
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MeSH Terms
Addison Disease / chemically induced*
Anesthesia / adverse effects*
Blood Gas Analysis
Electrolytes / blood
Etomidate / adverse effects*
Hydrocortisone / blood
Middle Aged
Pulse / drug effects
Reg. No./Substance:
0/Electrolytes; 33125-97-2/Etomidate; 437-38-7/Fentanyl; 50-23-7/Hydrocortisone; 548-73-2/Droperidol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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