Document Detail

Can the elimination of lactose from formula improve feeding tolerance in premature infants?
MedLine Citation:
PMID:  10547247     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether a low-lactose formula (LLF, <5% lactose) would ameliorate feeding intolerance in premature infants. STUDY DESIGN: Prospective, randomized, controlled trial involving 306 infants <36 weeks' gestation and weighing <1800 g who received either lactose-containing formula (LCF) 24 kcal/oz or a specially prepared LLF, which was comparable to the LCF except for the functional replacement of lactose with maltose. We examined outcome variables of feeding intolerance and cases of necrotizing enterocolitis (NEC) and suspected NEC. RESULTS: One hundred forty-nine infants were assigned to receive LCF, of which 99 infants received LCF only. One hundred fifty infants were assigned to receive LLF, of which 102 infants received LLF only. The remaining infants received LCF or LLF plus some quantity of human milk or human milk alone. Infants receiving LLF had improved enteral caloric intake and weight gain, reached full feeds faster, had less gastric residual, spent less time without oral intake, and had fewer feedings stopped than the LCF group. The number of cases of NEC and suspected NEC was similar in both groups. CONCLUSION: Low-lactose premature infant formula improved feeding tolerance. There was no evidence that LLF altered the incidence of NEC, but the incidence of NEC in this study was too low to draw conclusions.
M P Griffin; J W Hansen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  135     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-23     Completed Date:  1999-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  587-92     Citation Subset:  AIM; IM    
Department of Pediatrics, Division of Neonatology, University of Virginia, Charlottesville 22908, USA.
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MeSH Terms
Enterocolitis, Necrotizing / epidemiology,  prevention & control*
Infant Food*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology,  prevention & control*
Lactose* / administration & dosage
Lactose Intolerance
Maltose / administration & dosage
Milk, Human
Multivariate Analysis
Prospective Studies
Weight Gain
Reg. No./Substance:
63-42-3/Lactose; 69-79-4/Maltose
Comment In:
J Pediatr. 2001 Jan;138(1):148-9   [PMID:  11148537 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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