Document Detail


Can the elimination of lactose from formula improve feeding tolerance in premature infants?
MedLine Citation:
PMID:  10547247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine whether a low-lactose formula (LLF, <5% lactose) would ameliorate feeding intolerance in premature infants. STUDY DESIGN: Prospective, randomized, controlled trial involving 306 infants <36 weeks' gestation and weighing <1800 g who received either lactose-containing formula (LCF) 24 kcal/oz or a specially prepared LLF, which was comparable to the LCF except for the functional replacement of lactose with maltose. We examined outcome variables of feeding intolerance and cases of necrotizing enterocolitis (NEC) and suspected NEC. RESULTS: One hundred forty-nine infants were assigned to receive LCF, of which 99 infants received LCF only. One hundred fifty infants were assigned to receive LLF, of which 102 infants received LLF only. The remaining infants received LCF or LLF plus some quantity of human milk or human milk alone. Infants receiving LLF had improved enteral caloric intake and weight gain, reached full feeds faster, had less gastric residual, spent less time without oral intake, and had fewer feedings stopped than the LCF group. The number of cases of NEC and suspected NEC was similar in both groups. CONCLUSION: Low-lactose premature infant formula improved feeding tolerance. There was no evidence that LLF altered the incidence of NEC, but the incidence of NEC in this study was too low to draw conclusions.
Authors:
M P Griffin; J W Hansen
Related Documents :
3952317 - Coaxial balloon-catheter device for treatment of neonates and infants.
11012957 - Percutaneous central venous catheterization in small infants: axillary block can facili...
11387237 - Hypothesis: inappropriate colonization of the premature intestine can cause neonatal ne...
7161667 - A prospective evaluation of intestinal stenosis following necrotizing enterocolitis.
12827097 - The role of bath seats in unintentional infant bathtub drowning deaths.
19554807 - Higher frequency of screening tsh above 5 miu/l in infants likely exposed to higher dos...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  135     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-11-23     Completed Date:  1999-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  587-92     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Division of Neonatology, University of Virginia, Charlottesville 22908, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Enterocolitis, Necrotizing / epidemiology,  prevention & control*
Female
Humans
Infant Food*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / epidemiology,  prevention & control*
Lactose* / administration & dosage
Lactose Intolerance
Male
Maltose / administration & dosage
Milk, Human
Multivariate Analysis
Prospective Studies
Weight Gain
Chemical
Reg. No./Substance:
63-42-3/Lactose; 69-79-4/Maltose
Comments/Corrections
Comment In:
J Pediatr. 2001 Jan;138(1):148-9   [PMID:  11148537 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Longitudinal assessment of hemoglobin oxygen saturation in healthy infants during the first 6 months...
Next Document:  Risk factors for low bone mineral density in children and young adults with Crohn's disease.