Document Detail


Can elevated serum TRACP-5b levels predict stress fractures? A cohort study.
MedLine Citation:
PMID:  20218422     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: Stress fracture is a common overuse injury in athletes and military conscripts. The reliable diagnosis of stress fractures is often difficult, however, because it is usually based solely on radiographic findings. Biochemical markers of bone resorption reflect bone degradation and may also reflect the rate of bone loss. The aim of the study was to examine whether elevated serum tartrate-resistant acid phosphatase isoform 5b (TRACP-5b) levels reflect enhanced bone remodeling and predict the occurrence of stress fractures in military conscripts. MATERIAL AND METHODS: Randomly selected military conscripts [mean age, 19.8 (range 18-28) years; n = 820] were followed for 3 months. Baseline blood samples were drawn upon arrival to the service. Four subsequent samples were obtained from subjects that developed stress fractures and one sample each was obtained from two asymptomatic control subjects for each fracture case. RESULTS: Plain radiography was used to diagnose stress fractures in 20 of the 820 conscripts (2.4%). Follow-up data were available for 14 subjects with 21 stress fractures and 28 control subjects. Subjects with proportionally increasing serum TRACP-5b levels had an 8-fold greater probability of stress fracture than controls. No statistically significant difference was detected. CONCLUSIONS: Although assessing serum TRACP-5b levels appears to be a promising method to predict bone stress injuries, the present study failed to give a conclusive statement of its usefulness as a diagnostic tool.
Authors:
J-P S Ruohola; M Mulari; R I Haataja; H K V??n?nen; H K Pihlajam?ki
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society     Volume:  98     ISSN:  1457-4969     ISO Abbreviation:  Scand J Surg     Publication Date:  2009  
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-05-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101144297     Medline TA:  Scand J Surg     Country:  Finland    
Other Details:
Languages:  eng     Pagination:  239-43     Citation Subset:  IM    
Affiliation:
Centre for Military Medicine, Lahti, Finland. j-p.ruohola@pp.inet.fi
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MeSH Terms
Descriptor/Qualifier:
Acid Phosphatase / blood*
Adolescent
Adult
Biological Markers / blood
Cohort Studies
Female
Fracture Healing / physiology
Fractures, Stress / blood*,  diagnosis*,  epidemiology
Humans
Isoenzymes / blood*
Male
Military Personnel*
Predictive Value of Tests
Reproducibility of Results
Time Factors
Young Adult
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Isoenzymes; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.2/Acid Phosphatase

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