| Can elevated serum TRACP-5b levels predict stress fractures? A cohort study. | |
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MedLine Citation:
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PMID: 20218422 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND AIMS: Stress fracture is a common overuse injury in athletes and military conscripts. The reliable diagnosis of stress fractures is often difficult, however, because it is usually based solely on radiographic findings. Biochemical markers of bone resorption reflect bone degradation and may also reflect the rate of bone loss. The aim of the study was to examine whether elevated serum tartrate-resistant acid phosphatase isoform 5b (TRACP-5b) levels reflect enhanced bone remodeling and predict the occurrence of stress fractures in military conscripts. MATERIAL AND METHODS: Randomly selected military conscripts [mean age, 19.8 (range 18-28) years; n = 820] were followed for 3 months. Baseline blood samples were drawn upon arrival to the service. Four subsequent samples were obtained from subjects that developed stress fractures and one sample each was obtained from two asymptomatic control subjects for each fracture case. RESULTS: Plain radiography was used to diagnose stress fractures in 20 of the 820 conscripts (2.4%). Follow-up data were available for 14 subjects with 21 stress fractures and 28 control subjects. Subjects with proportionally increasing serum TRACP-5b levels had an 8-fold greater probability of stress fracture than controls. No statistically significant difference was detected. CONCLUSIONS: Although assessing serum TRACP-5b levels appears to be a promising method to predict bone stress injuries, the present study failed to give a conclusive statement of its usefulness as a diagnostic tool. |
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Authors:
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J-P S Ruohola; M Mulari; R I Haataja; H K V??n?nen; H K Pihlajam?ki |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society Volume: 98 ISSN: 1457-4969 ISO Abbreviation: Scand J Surg Publication Date: 2009 |
Date Detail:
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Created Date: 2010-03-11 Completed Date: 2010-05-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101144297 Medline TA: Scand J Surg Country: Finland |
Other Details:
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Languages: eng Pagination: 239-43 Citation Subset: IM |
Affiliation:
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Centre for Military Medicine, Lahti, Finland. j-p.ruohola@pp.inet.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid Phosphatase
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blood* Adolescent Adult Biological Markers / blood Cohort Studies Female Fracture Healing / physiology Fractures, Stress / blood*, diagnosis*, epidemiology Humans Isoenzymes / blood* Male Military Personnel* Predictive Value of Tests Reproducibility of Results Time Factors Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Isoenzymes; EC 3.1.3.-/tartrate-resistant acid phosphatase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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