Document Detail

Can early introduction of egg prevent egg allergy in infants? A population-based study.
MedLine Citation:
PMID:  20920771     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infant feeding guidelines have long recommended delaying introduction of solids and allergenic foods to prevent allergy in high-risk infants, despite a paucity of evidence.
OBJECTIVE: We aimed to determine whether confirmed egg allergy in 12-month-old infants is associated with (1) duration of breast-feeding and (2) ages of introducing egg and solids.
METHODS: In a population-based cross-sectional study (HealthNuts) parents reported on infant feeding and potential confounding factors before skin prick testing for egg white. Egg-sensitized infants were then offered an egg oral food challenge. Multiple logistic regression was used to investigate associations between diet and egg allergy adjusted for possible confounding factors.
RESULTS: A total of 2589 infants (73% response) participated. Compared with introduction at 4 to 6 months, introducing egg into the diet later was associated with higher risks of egg allergy (adjusted odds ratios [ORs], 1.6 [95% CI, 1.0-2.6] and 3.4 [95% CI, 1.8-6.5] for introduction at 10-12 and after 12 months, respectively). These findings persisted even in children without risk factors (OR, 3.3 [95% CI, 1.1-9.9]; 10-12 months). At age 4 to 6 months, first exposure as cooked egg reduced the risk of egg allergy compared with first exposure as egg in baked goods (OR, 0.2 [95% CI, 0.06-0.71]). Duration of breast-feeding and age at introduction of solids were not associated with egg allergy.
CONCLUSIONS: Introduction of cooked egg at 4 to 6 months of age might protect against egg allergy. Changes in infant feeding guidelines could have a significant effect on childhood egg allergy and possibly food allergy more generally.
Jennifer J Koplin; Nicholas J Osborne; Melissa Wake; Pamela E Martin; Lyle C Gurrin; Marnie N Robinson; Dean Tey; Marjolein Slaa; Leone Thiele; Lucy Miles; Deborah Anderson; Tina Tan; Thanh D Dang; David J Hill; Adrian J Lowe; Melanie C Matheson; Anne-Louise Ponsonby; Mimi L K Tang; Shyamali C Dharmage; Katrina J Allen
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  126     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-11-12     Revised Date:  2011-08-22    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  807-13     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
Murdoch Childrens Research Institute, Parkville, Australia.
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MeSH Terms
Age Factors
Breast Feeding
Cross-Sectional Studies
Egg Hypersensitivity / epidemiology,  etiology,  prevention & control*
Eggs / adverse effects*
Guidelines as Topic
Population Surveillance / methods
Risk Factors
Comment In:
Curr Allergy Asthma Rep. 2011 Aug;11(4):269-70   [PMID:  21484312 ]

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