Document Detail

Can dynamic MR imaging predict response in patients with rectal cancer undergoing cetuximab-based neoadjuvant chemoradiation?
MedLine Citation:
PMID:  19295245     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The aim of this study was to evaluate therapy response in patients undergoing cetuximab-CapIri-based chemoradiation for rectal cancer using dynamic magnetic resonance imaging (dMRI).
PATIENTS AND METHODS: The volumetric degree of tumor regression and contrast media perfusion were compared to the results of the histopathologic ypTN staging. 33 patients were examined using a 1.5-T scanner with repetitive 2D FLASH sequences after contrast media application. All patients were examined twice - before therapy and immediately before surgery.
RESULTS: In all patients, the tumor volume decreased (mean 72 +/- 16%). In 25/33 patients, the slope of the contrast media enhancement curve decreased (mean 31 +/- 20%). In histopathologically proven downstaging after therapy, the decrease in slope was significantly higher than in the group without downstaging, and the decrease in slope was better for distinguishing between 'responder' and 'non-responder' than the decrease in volume.
CONCLUSION: Using dMRI helps to identify responders undergoing cetuximab-based chemoradiation better than volume decrease alone.
Dietmar J Dinter; Karoline Horisberger; Christian Zechmann; Frederik Wenz; Joachim Brade; Frank Willeke; K Wolfgang Neff; Stefan O Schoenberg; Ralf-Dieter Hofheinz
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2009-02-13
Journal Detail:
Title:  Onkologie     Volume:  32     ISSN:  1423-0240     ISO Abbreviation:  Onkologie     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-19     Completed Date:  2009-04-28     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  7808556     Medline TA:  Onkologie     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  86-93     Citation Subset:  IM    
Copyright Information:
Copyright 2009 S. Karger AG, Basel.
Institut für Klinische Radiologie und Nuklearmedizin, Medizinische Fakultät Mannheim der Universität Heidelberg, Heidelberg, Germany.
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MeSH Terms
Antibodies, Monoclonal / administration & dosage*
Antineoplastic Agents / administration & dosage
Magnetic Resonance Imaging / methods*
Middle Aged
Radiotherapy, Adjuvant / methods
Radiotherapy, Conformal*
Rectal Neoplasms / diagnosis*,  therapy*
Reproducibility of Results
Sensitivity and Specificity
Treatment Outcome
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antineoplastic Agents; PQX0D8J21J/cetuximab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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