Document Detail

Can dopamine agonist at a low dose reduce ovarian hyperstimulation syndrome in women at risk undergoing ICSI treatment cycles? A randomized controlled study.
MedLine Citation:
PMID:  22948132     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Dopamine agonists were proposed as a preventive strategy for severe ovarian. The aim of this randomized controlled study is to evaluate the role of dopamine agonist at lower doses (0.25mg) as a preventive strategy of severe hyperstimulation syndrome (OHSS) in women at high risk in IVF/ICSI treatment cycles.
STUDY DESIGN: Two hundred women at risk to develop OHSS undergoing IVF/ICSI treatment cycle were included; the study group received 0.25mg of cabergoline for 8 days from the day of HCG administration versus no treatment for the prevention of OHSS. Reduction of the incidence OHSS was the primary outcome.
RESULTS: The overall incidence of OHSS was significantly reduced, almost 50%, in cabergoline group in comparison with control group (RR: 0.5, 95% CI: 0.29-0.83), with absolute risk reduction following cabergoline administration 11% (ARR: 0.11, 95% CI: 1.09-20.91). The corresponding number needed to treat (NNT) was 9.
CONCLUSION: Prophylactic treatment with the dopamine agonist, cabergoline, at lower doses (0.25mg) reduces the incidence of OHSS in women at high risk undergoing IVF/ICSI treatment.
Amany Shaltout; Amal Shohyab; Mohamed A F M Youssef
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2012-09-01
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  165     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  2013-05-16     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  254-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Dr. Samir Abbas Medical Center, Jeddah, Saudi Arabia.
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MeSH Terms
Dopamine Agonists / therapeutic use*
Ergolines / therapeutic use*
Ovarian Hyperstimulation Syndrome / prevention & control*
Sperm Injections, Intracytoplasmic
Reg. No./Substance:
0/Dopamine Agonists; 0/Ergolines; LL60K9J05T/cabergoline

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