Document Detail

Can cytokines be removed by hemofiltration or hemoadsorption?
MedLine Citation:
PMID:  10926144     Owner:  NLM     Status:  MEDLINE    
To study the removability of pro-inflammatory cytokines by hemofiltration (HF), we performed experimental HF with various high-flux membranes (HFM) using a closed circuit system filled with monocyte-free human plasma, which contained TNFalpha, IL-1beta, and IL-6. Plasma and filtrate samples were taken before and 1, 2, 3, and 4 hours after the initiation of HF, and each cytokine was determined by enzyme-linked immunosorbent assay. IL-1beta was well removed through filtration during experimental HF using HFM (PAN>CTA>PMMA>PS). TNFalpha and IL-6 were only minimally filtered out by HF using HFM. TNFalpha was removed to some extent by using PS, and IL-6 was partially removed by using PMMA during experimental HF through other mechanisms, such as adsorption, than the filtration. IL-1beta and IL-6 were effectively removed by HA using charcoal adsorbent column, especially during the first 2 hours, while TNFalpha was only partly removed.
S Teraoka; M Mineshima; T Hoshino; I Ishimori; I Kaneko; Y Sato; H Haruguchi; T Agishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  46     ISSN:  1058-2916     ISO Abbreviation:  ASAIO J.     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2000-11-28     Completed Date:  2000-11-28     Revised Date:  2006-05-23    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  448-51     Citation Subset:  IM    
Kidney Center, Faculty of Medicine, Tokyo Women's Medical University, Japan.
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MeSH Terms
Cytokines / isolation & purification*
Interleukin-1 / isolation & purification
Interleukin-6 / isolation & purification
Tumor Necrosis Factor-alpha / isolation & purification
Reg. No./Substance:
0/Cytokines; 0/Interleukin-1; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

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