Document Detail

Can cumulative pregnancy rates be increased by freezing and thawing single embryos?
MedLine Citation:
PMID:  18295209     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the extent to which transfers of frozen single embryos increase cumulative pregnancy rates. DESIGN: Retrospective analysis. SETTING: IVF unit of a university hospital. PATIENT(S): Patients undergoing IVF cycles that were carried out from 2001 to 2005 (n = 1758). Patients were assigned to three groups according to the number of embryos frozen: group A, no cryopreservation; group B, a single embryo frozen; group C, several embryos frozen. INTERVENTION(S): Analysis of fresh ETs as a function of the number of embryos frozen and comparison outcomes for the thawing of a single embryo between subgroups B* (only one embryo frozen and thawed) and C* (last embryo of the cohort thawed). MAIN OUTCOME MEASURE(S): Implantation and pregnancy rates after fresh ETs and embryo survival and pregnancy rates after the transfer of a single thawed embryo. RESULT(S): The pregnancy rate per fresh ET increased significantly with the number of embryos frozen: 16.2% in group A, 21.4% in group B, and 26.5% in group C. For single thawed embryos, survival was higher in group C* (91.7%) than in group B* (72.6%). The pregnancy rate was also significantly higher in group C* (19.4% vs. 0%). CONCLUSION(S): The freezing of single embryos is of no benefit in cumulative pregnancy rates. ET strategies should therefore be reviewed.
Marie Prades; Jean-Louis Golmard; Danièle Vauthier; Gilles Lefèbvre; Catherine Poirot
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-03-04
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-02-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-400     Citation Subset:  IM    
Reproductive Biology Unit, University Hospital, Hôpital Pitié-Salpêtrière, Paris, France.
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MeSH Terms
Embryo Implantation*
Embryo Transfer*
Embryo, Mammalian*
Fertilization in Vitro*
Pregnancy Rate*
Retrospective Studies
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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