Document Detail


Can consumption of raw vegetables decrease the count of sister chromatid exchange? Results from a cross-sectional study in Krakow, Poland.
MedLine Citation:
PMID:  24740589     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Sister chromatid exchange (SCE) is a widely used sensitive cytogenetic biomarker of exposure to genotoxic and cancerogenic agents. Results of human monitoring studies and cytogenetic damage have revealed that biological effects of genotoxic exposures are influenced by confounding factors related to life-style. Vegetable and fruit consumption may play a role, but available results are not consistent. The purpose of the study was to investigate the effect of consumption of raw and cooked vegetables and fruits on SCE frequency.
METHODS: A total of 62 participants included colorectal cancer (CRC) patients, hospital-based controls and healthy laboratory workers. SCE frequency was assessed in blood lymphocytes. Frequency of vegetable and fruit consumption was gathered by structured semi-quantitative food frequency questionnaire.
RESULTS: SCE frequency was lowest among hospital-based controls (4.4 ± 1.1), a bit higher in CRC patients (4.5 ± 1.0) and highest among laboratory workers (7.4 ± 1.2) (p < 0.05). Multivariable linear regression showed a significant inverse effect (b = -0.20) of raw vegetable consumption, but not so for intake of cooked vegetables and fruits.
CONCLUSIONS: The results of the study have shown the beneficial effect of consumption of raw vegetables on disrupted replication of DNA measured by SCE frequency, implying protection against genotoxic agents. Further effort is required to verify the role of cooked vegetables and fruits.
Authors:
Aleksander Galas; Antonina Cebulska-Wasilewska
Related Documents :
22475339 - Advanced nanoemulsions.
1032129 - Nickel dermatitis--nickel excretion.
24666779 - Adaptation to short photoperiods augments circadian food anticipatory activity in siber...
17521889 - The relationship of personality traits to substance abuse in patients with bipolar diso...
157249 - Contact dermatitis from hydrazine derivatives.
25410129 - Nutritional values and bioactive components of underutilized vegetables consumed by ind...
7054259 - Soup-to-nuts: a television approach to nutrition education.
17472469 - Immunomodulation by a malleable matrix composed of fermented whey proteins and lactic a...
24621049 - Dietary intake and adherence to the 2010 dietary guidelines for americans among individ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-4-17
Journal Detail:
Title:  European journal of nutrition     Volume:  -     ISSN:  1436-6215     ISO Abbreviation:  Eur J Nutr     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-4-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888704     Medline TA:  Eur J Nutr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Consumption of a dark roast coffee decreases the level of spontaneous DNA strand breaks: a randomize...
Next Document:  Changes in the serum metabolite profile in obese children with weight loss.