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Can conjunctival provocation test facilitate the diagnosis of food allergy in children?
MedLine Citation:
PMID:  20605314     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Food allergy is common in children, occurring in 5-7.5%. The diagnosis may, however, be difficult. Elevated IgE or positive skin prick test to a food allergen is often considered proof of allergy, but may represent sensitisation without clinical manifestations. For a precise diagnosis oral challenge is necessary, but this is often not performed because of risk of serious allergic reactions. The aim of this study was to evaluate whether conjunctival provocation test would facilitate the diagnosis of IgE-mediated food allergy.
METHODS: One hundred and forty-nine children with 174 possible diagnoses of food allergy were included. General examination, skin prick test and specific IgE were performed, as well as conjunctival provocation test of the suspected food allergen. Open food challenges and double-blind placebo controlled tests were performed in order to diagnose possible food allergy.
RESULTS: Forty-six children with strongly positive conjunctival reactions (rubor, itching, oedema) to fifty food allergens were all proven to have allergy to the food in question. The children with negative conjunctival provocation tests showed no allergic reactions when challenged.
CONCLUSIONS: We find that a strongly positive conjunctival reaction to a food allergen correlates well with true allergy. An oral challenge should be carefully performed. With a negative conjunctival test an oral challenge may safely be performed.
Authors:
B Krane Kvenshagen; M Jacobsen; R Halvorsen
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Publication Detail:
Type:  Journal Article     Date:  2010-06-04
Journal Detail:
Title:  Allergologia et immunopathologia     Volume:  38     ISSN:  1578-1267     ISO Abbreviation:  Allergol Immunopathol (Madr)     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370073     Medline TA:  Allergol Immunopathol (Madr)     Country:  Spain    
Other Details:
Languages:  eng     Pagination:  321-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2009 SEICAP. Published by Elsevier Espana. All rights reserved.
Affiliation:
Oestfold Hospital Trust, Department of Pediatrics, Fredrikstad, Norway. bent-kv@online.no
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