| Can a commercial diagnostic ultrasound device accelerate thrombolysis? An in vitro skull model. | |
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MedLine Citation:
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PMID: 15591211 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: Recently, 3 clinical trials revealed encouraging results in recanalization and clinical outcome in acute stroke patients when 2-MHz transcranial Doppler monitoring was applied. This study investigated whether a 1.8-MHz commercial diagnostic ultrasound device has the potential to facilitate thrombolysis using an in vitro stroke model. METHODS: Duplex-Doppler, continuous wave-Doppler, and pulsed wave (PW)-Doppler were compared on their impact on recombinant tissue plasminogen activator (rtPA)-mediated thrombolysis. Blood clots were transtemporally sonicated in a human stroke model. Furthermore, ultrasound attenuation of 5 temporal bones of different thickness was determined. RESULTS: In comparison, only PW-Doppler accelerated rtPA-mediated thrombolysis significantly. Without temporal bone, PW-Doppler plus rtPA showed a significant enhancement in relative clot weight loss of 23.7% when compared with clots treated with rtPA only (33.9+/-5.5% versus 27.4+/-5.2%; P<0.0005). Ultrasound attenuation measurements revealed decreases of the output intensity of 86.8% (8.8 dB) up to 99.2% (21.2 dB), depending on temporal bone thickness (1.91 to 5.01 mm). CONCLUSIONS: Without temporal bone, PW-Doppler significantly enhanced thrombolysis. However, because of a high attenuation of ultrasound by temporal bone, no thrombolytic effect was observed in our in vitro model, although Doppler imaging through the same temporal bone was still possible. |
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Authors:
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Stefan Pfaffenberger; Branka Devcic-Kuhar; Christian Kollmann; Stefan P Kastl; Christoph Kaun; Walter S Speidl; Thomas W Weiss; Svitlana Demyanets; Robert Ullrich; Heinz Sochor; Christian Wöber; Josef Zeitlhofer; Kurt Huber; Martin Gröschl; Ewald Benes; Gerald Maurer; Johann Wojta; Michael Gottsauner-Wolf |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; In Vitro; Journal Article; Research Support, Non-U.S. Gov't Date: 2004-12-09 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: 36 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2004-12-24 Completed Date: 2005-09-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
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Languages: eng Pagination: 124-8 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine II, University of Vienna, Austria. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation Fibrinolytic Agents / pharmacology, therapeutic use Humans Male Skull / ultrasonography* Stroke / blood, drug therapy*, ultrasonography Temporal Bone / ultrasonography Thrombolytic Therapy / instrumentation* Tissue Plasminogen Activator / pharmacology, therapeutic use Ultrasonography, Doppler, Duplex Ultrasonography, Doppler, Pulsed Ultrasonography, Doppler, Transcranial* |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
| Comments/Corrections | |
Comment In:
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Stroke. 2005 May;36(5):929-30; author reply 930-1
[PMID:
15867163
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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