Document Detail

Can birth weight standards based on healthy populations improve the identification of small-for-gestational-age newborns at risk of adverse neonatal outcomes?
MedLine Citation:
PMID:  19171644     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To develop neonatal growth standards based on (1) the entire population of live births and (2) a healthy subpopulation and compare them in identifying infants as small for gestational age and at risk of adverse neonatal outcomes. PATIENTS AND METHODS: We included all births, between 28 and 41 weeks of gestation, reported in Burgundy (France) from 2000 to 2006. Fetal deaths, multiple births, and chromosomal aberrations were excluded. We first estimated separate birth weight distributions at each week of gestation for (1) all neonates and (2) only infants born from women without maternal diseases. Small for gestational age was defined as a birth weight below the 10th percentile of the corresponding standard. We assessed the associations of small for gestational age on the basis of the alternative definitions, with mortality and major neonatal outcomes. RESULTS: We included 127 584 live births. For term newborns, small for gestational age was significantly associated with an increased risk of death with both standards. In contrast, for preterm newborns (32-36 weeks), small for gestational age was not significantly associated with mortality and morbidity. Very preterm infants (28-31 weeks) identified as small for gestational age according to the healthy-population standard were at higher risk of chronic lung disease and intraventricular hemorrhage. When using the entire-population standard, small for gestational age was associated with chronic lung disease but not intraventricular hemorrhage. The area under the receiver operating characteristic for predicting an intraventricular hemorrhage was significantly greater for small for gestational age defined with the healthy-population standard compared with small for gestational age classified with the entire-population standard. CONCLUSIONS: Neonatal growth standards based on healthy populations could improve the identification of very preterm neonates as small for gestational age and at risk of intraventricular hemorrhage.
Cyril Ferdynus; Catherine Quantin; Michal Abrahamowicz; Robert Platt; Antoine Burguet; Paul Sagot; Christine Binquet; Jean-Bernard Gouyon
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Pediatrics     Volume:  123     ISSN:  1098-4275     ISO Abbreviation:  Pediatrics     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-27     Completed Date:  2009-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376422     Medline TA:  Pediatrics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723-30     Citation Subset:  AIM; IM    
Cellule d'Evaluation du Réseau Périnatal de Bourgogne, 1 Boulevard Jeanne d'Arc, B P-77908, 21079 Dijon Cedex, France.
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MeSH Terms
Birth Weight*
Gestational Age
Infant, Newborn
Infant, Newborn, Diseases / diagnosis*,  epidemiology*
Infant, Premature*
Infant, Small for Gestational Age*
Reference Values
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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