Document Detail

Can beta stiffness index be proposed as risk factor for dementia.
MedLine Citation:
PMID:  19286194     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIM: Changes of arterial stiffness indicate alteration in arterial mechanics predisposing to the evolution of stroke or vascular dementia. The aim of this pilot study was to investigate whether ultrasound parameters, particularly beta stiffness index (BSI), should be further explored as independent markers or risk factors for dementia. PATIENTS AND METHODS: There were 38 demented patients included in this study (72.53+/-7.87 yrs) and 33 clinically healthy controls (68.85+/-3.52 yrs). Risk factors were noted and ultrasound measurements performed on common carotid artery (CCA) using eTracking software on Aloka ProSound ALPHA 10 with 13 MHz linear probe. Level of significance was p<0.05. RESULTS: Arterial hypertension was present in 24 patients, atrial fibrillation in 9, diabetes in 3, and hypercholesterolemia in 18. Hypertension was present as a single risk factor in 15 controls with average diastolic blood pressure significantly lower in patients. Significantly higher in patients were mean intima-media thickness, systolic and diastolic CCA diameters (CD), and mean BSI in CCA bilaterally. Linear regression analysis for groups of Alzheimer's dementia and vascular dementia proved that MMSE of the two groups relates to CCA diameter change (CDc) and BSI change explaining up to 5% of variability. CONCLUSIONS: CD, CDc and BSI should be monitored in patients with cognitive decline and further explored as possible independent markers or risk factors; in future studies groups of demented and non-demented patients should be age, sex and risk factor matched.
Miljenka-Jelena Jurasic; Irena Martinic Popovic; Sandra Morovic; Zlatko Trkanjec; Vesna Seric; Vida Demarin
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Publication Detail:
Type:  Journal Article     Date:  2009-03-16
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  283     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-20     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  13-6     Citation Subset:  IM    
University Department of Neurology, Sestre Milosrdnice University Hospital, Vinogradska 29, 10 000 Zagreb, Croatia.
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MeSH Terms
Alzheimer Disease / epidemiology,  pathology,  ultrasonography
Atrial Fibrillation / epidemiology
Carotid Artery, Common / pathology,  ultrasonography*
Dementia / epidemiology*,  pathology,  ultrasonography*
Dementia, Vascular / epidemiology,  pathology,  ultrasonography
Diabetes Mellitus / epidemiology
Hypercholesterolemia / epidemiology
Hypertension / epidemiology
Linear Models
Pilot Projects
Psychiatric Status Rating Scales
Regression Analysis
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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