| Can beta-blocker therapy be withdrawn from patients with dilated cardiomyopathy? | |
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MedLine Citation:
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PMID: 10467195 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: It has yet to be determined whether withdrawing beta-blocker therapy from patients with dilated cardiomyopathy (DCM) is safe. METHODS: The influence of tapering and then stopping metoprolol was clarified in 13 patients with DCM who had been receiving this agent for >/=30 months. RESULTS: Seven of the 13 patients deteriorated, including 4 who died suddenly or of congestive heart failure during the 4-month period after metoprolol cessation. CONCLUSION: In patients with DCM in whom beta-blocker therapy is effective, withdrawal of these agents may lead to death. We conclude that beta-blockers should not be stopped in this patient group. |
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Authors:
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S Morimoto; K Shimizu; K Yamada; S Hiramitsu; H Hishida |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 138 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-09-22 Completed Date: 1999-09-22 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 456-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Department of Internal Medicine, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic beta-Antagonists
/
administration & dosage*,
adverse effects,
therapeutic use Adult Aged Cardiomyopathy, Dilated / drug therapy*, pathology Death, Sudden, Cardiac Female Follow-Up Studies Humans Male Middle Aged Substance Withdrawal Syndrome* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic beta-Antagonists |
| Comments/Corrections | |
Comment In:
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Am Heart J. 1999 Sep;138(3 Pt 1):387-9
[PMID:
10467182
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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