Document Detail

Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
MedLine Citation:
PMID:  23001575     Owner:  NLM     Status:  Publisher    
The mechanisms by which dietary restriction of the amino acid methionine exerts beneficial effects on oxidative damage towards rat liver mitochondria are discussed. It is suggested that methionine restriction decreases amino acid utilization in protein synthesis which, by decreasing synthesis of non-essential amino acids from carbohydrate precursors, also decreases formation of the highly deleterious glycolytic by-product methylglyoxal, a well-recognised source of age-related damage including formation of reactive oxygen species, mitochondrial dysfunction and proteotoxicity. Additionally, decreased protein synthesis will lower the error-protein load which the protein quality system (proteasomal and autophagic) must deal with to maintain proteostasis.
Alan R Hipkiss
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-23
Journal Detail:
Title:  Biogerontology     Volume:  -     ISSN:  1389-5729     ISO Abbreviation:  Biogerontology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Aston Research Centre for Healthy Ageing (ARCHA), School of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK,
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