Document Detail


Can the beneficial effects of methionine restriction in rats be explained in part by decreased methylglyoxal generation resulting from suppressed carbohydrate metabolism?
MedLine Citation:
PMID:  23001575     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The mechanisms by which dietary restriction of the amino acid methionine exerts beneficial effects on oxidative damage towards rat liver mitochondria are discussed. It is suggested that methionine restriction decreases amino acid utilization in protein synthesis which, by decreasing synthesis of non-essential amino acids from carbohydrate precursors, also decreases formation of the highly deleterious glycolytic by-product methylglyoxal, a well-recognised source of age-related damage including formation of reactive oxygen species, mitochondrial dysfunction and proteotoxicity. Additionally, decreased protein synthesis will lower the error-protein load which the protein quality system (proteasomal and autophagic) must deal with to maintain proteostasis.
Authors:
Alan R Hipkiss
Related Documents :
23800855 - Differential regulation of abca1 and macrophage cholesterol efflux by elaidic and oleic...
23994365 - Reducing mechanical activation-induced amorphisation of salbutamol sulphate by co-proce...
24318055 - The kinetics of bidirectional growth of stem sections from etiolated pea seedlings in r...
23325675 - A dual-functional metallogel of amphiphilic copper(ii) quinolinol: redox responsiveness...
2081205 - A sensitive assay for clavulanic acid and sulbactam in biological fluids by high-perfor...
24886955 - Direct synthesis of formic acid from carbon dioxide by hydrogenation in acidic media.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-23
Journal Detail:
Title:  Biogerontology     Volume:  -     ISSN:  1389-5729     ISO Abbreviation:  Biogerontology     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930043     Medline TA:  Biogerontology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Aston Research Centre for Healthy Ageing (ARCHA), School of Health and Life Sciences, Aston University, Birmingham, B4 7ET, UK, alanandjill@lineone.net.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  ESPR Uroradiology Task Force and ESUR Paediatric Working Group-Imaging recommendations in paediatric...
Next Document:  EBV primary infection in childhood and its relation to B-cell lymphoma development: A mini-review fr...