| Can autophagy promote longevity? | |
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MedLine Citation:
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PMID: 20811357 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Organismal lifespan can be extended by genetic manipulation of cellular processes such as histone acetylation, the insulin/IGF-1 (insulin-like growth factor 1) pathway or the p53 system. Longevity-promoting regimens, including caloric restriction and inhibition of TOR with rapamycin, resveratrol or the natural polyamine spermidine, have been associated with autophagy (a cytoprotective self-digestive process) and in some cases were reported to require autophagy for their effects. We summarize recent developments that outline these links and hypothesize that clearing cellular damage by autophagy is a common denominator of many lifespan-extending manipulations. |
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Authors:
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Frank Madeo; Nektarios Tavernarakis; Guido Kroemer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature cell biology Volume: 12 ISSN: 1476-4679 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-02 Completed Date: 2010-10-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 842-6 Citation Subset: IM |
Affiliation:
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Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology Animals Autophagy / drug effects, physiology* Caenorhabditis elegans / physiology Caloric Restriction Cell Aging / physiology Cytoprotection / physiology Drosophila melanogaster / physiology Humans Immune System / physiology Immunity / physiology Longevity / drug effects, physiology* Mice Receptor, IGF Type 1 / genetics Saccharomyces cerevisiae / physiology Sirolimus / pharmacology Sirtuin 1 / genetics Spermidine / pharmacology Stilbenes / pharmacology Tumor Suppressor Protein p53 / genetics |
| Chemical | |
Reg. No./Substance:
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0/Stilbenes; 0/Tumor Suppressor Protein p53; 124-20-9/Spermidine; 501-36-0/resveratrol; 53123-88-9/Sirolimus; EC 2.7.10.1/Receptor, IGF Type 1; EC 3.5.1.-/Sirtuin 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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