Document Detail

Can atherosclerotic plaques regress? Anatomic and biochemical evidence from nonhuman animal models.
MedLine Citation:
PMID:  2180269     Owner:  NLM     Status:  MEDLINE    
For at least 60 years, spotty and poorly documented evidence has suggested that atherosclerotic disease in humans might be reversible. Little direct evidence was available until researchers demonstrated that rather advanced atherosclerotic lesions in experimental animals could show marked improvement after blood-lipid-reducing regimens that were often combined with other measures, such as increased ambient oxygen and estradiol therapy. In fact, this combination was used in this laboratory to produce one of the first effective regression studies in the rabbit model. In more recent studies in this laboratory, abundant evidence has been obtained that the advanced, eccentric, largely intimal lesions produced in the rhesus monkey are substantially reversible, and the much more inflammatory, concentric, and often transmural atheroarteritis induced by the same atherogenic ration in the cynomolgus monkeys is much more resistant to effective and beneficial regression. This unusual reaction appears to be due to the circulating immune complexes that participate in the pathogenesis of atherosclerosis in these cynomolgus monkeys, as well as possibly in a number of humans. The evidence for this phenomenon, as well as the varying effects of the lesions induced with contrasting food fats, is summarized in this presentation. Some of the time-related effects of varying interventions when the lesions are studied at 4-month intervals in rhesus and cynomolgus monkeys are also discussed. Other factors that may influence regression are also considered.
R W Wissler; D Vesselinovitch
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  65     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1990-04-19     Completed Date:  1990-04-19     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  33F-40F     Citation Subset:  AIM; IM    
Department of Pathology, University of Chicago Medical Center, Illinois 60637.
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MeSH Terms
Arteriosclerosis / diet therapy,  drug therapy,  pathology*
Blood Vessels / pathology
Diet, Atherogenic
Disease Models, Animal*
Macaca fascicularis
Macaca mulatta
Grant Support
15062//PHS HHS; R10-HL33740/HL/NHLBI NIH HHS

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